TAILIEUCHUNG - Báo cáo khoa học: Docking proteins

Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. | MINIREVIEW Docking proteins Tilman Brummer1 2 3 Carsten Schmitz-Peiffer4 and Roger J. Daly5 1 Centre for BiologicalSystems Analysis ZBSA Albert-Ludwigs-University of Freiburg Germany 2 Institute for Biology III Albert-Ludwigs-University of Freiburg Germany 3 Centre for BiologicalSignalling Studies Albert-Ludwigs-University of Freiburg Germany 4 Diabetes and Obesity Program Garvan Institute of MedicalResearch Sydney Australia 5 Cancer Research Program Garvan Institute of MedicalResearch Sydney Australia Keywords Dok DOS FRS2 Gab IRS protein modules protein phosphorylation SH2 signal transduction tyrosine kinase Correspondence R. J. Daly Cancer Research Program Garvan Institute of Medical Research Sydney NSW 2010 Australia Fax 61 2 9295 8321 Tel 61 2 9295 8333 E-mail Received 19 May 2010 revised 1 August 2010 accepted 23 August 2010 doi Docking proteins comprise a distinct category of intracellular noncatalytic signalling protein that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder Daughter of Sevenless insulin receptor substrate fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure function and regulation of these proteins. Overview In a review on receptor tyrosine kinase RTK signalling published a decade ago 1 docking proteins were classified as signal transducers that exhibit a membrane targeting region at the N-terminus and multiple tyrosine phosphorylation sites that function as binding sites for src homology SH 2 domains of a variety of downstream effectors. Proteins that fell into this category were members of the growth factor receptor bound Grb 2-associated binder Gab Daughter of Sevenless DOS insulin receptor substrate IRS fibroblast growth .

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