TAILIEUCHUNG - Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression

Heat shock factor (HSF) is an evolutionarily conserved stress-response reg-ulator that activates the transcription of heat shock protein genes, whose products maintain protein homeostasis under normal physiological condi-tions, as well as under conditions of stress. The promoter regions of the target genes contain a heat shock element consisting of multiple inverted repeats of the pentanucleotide sequence nGAAn. | MINIREVIEW Novel aspects of heat shock factors DNA recognition chromatin modulation and gene expression Hiroshi Sakurai and Yasuaki Enoki Department of ClinicalLaboratory Science Kanazawa University Graduate Schoolof MedicalScience Ishikawa Japan Keywords chromatin heat shock element heat shock transcription factor histone protein-DNA interactions Correspondence H. Sakurai Department of Clinical Laboratory Science Kanazawa University Graduate Schoolof MedicalScience 5-11-80 Kodatsuno Kanazawa Ishikawa 920-0942 Japan Fax 81 76 234 4369 Tel 81 76 265 2588 E-mail sakurai@ Received 10 May 2010 revised 9 July 2010 accepted 23 July 2010 doi Heat shock factor HSF is an evolutionarily conserved stress-response regulator that activates the transcription of heat shock protein genes whose products maintain protein homeostasis under normal physiological conditions as well as under conditions of stress. The promoter regions of the target genes contain a heat shock element consisting of multiple inverted repeats of the pentanucleotide sequence nGAAn. A single HSF of yeast can bind to heat shock elements that differ in the configuration of the nGAAn units and can regulate the transcription of various genes that function not only in stress resistance but also in a broad range of biological processes. Mammalian cells have four HSF family members involved in different but in some cases similar biological functions including stress resistance cell differentiation and development. Mammalian HSF family members exhibit differential specificity for different types of heat shock elements which together with cell type-specific expression of HSFs is important in determining the target genes of each HSF. This minireview focuses on the molecular mechanisms of DNA recognition chromatin modulation and gene expression by yeast and mammalian HSFs. Background The heat shock factor HSF in eukaryotes is involved not only in heat shock protein

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