TAILIEUCHUNG - Báo cáo khoa học: High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states – an unusual flavodoxin

The small flavoprotein NrdI is an essential component of the class Ib ribo-nucleotide reductase system in many bacteria. NrdI interacts with the class Ib radical generating protein NrdF. It is suggested to be involved in the rescue of inactivated diferric centres or generation of active dimanganese centres in NrdF. | High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states - an unusual flavodoxin Structural biology Renzo Johansson1 Eduard Torrents2 Daniel Lundin3 Janina Sprenger1 Margareta Sahlin3 Britt-Marie Sjoberg3 and Derek T. Logan1 1 Department of Biochemistry and StructuralBiology Lund University Sweden 2 Cellular Biotechnology Institute for Bioengineering of Catalonia Barcelona Spain 3 Department of Molecular Biology and FunctionalGenomics Stockholm University Sweden Keywords crystal structure flavin mononucleotide flavodoxin NrdI ribonucleotide reductase Correspondence D. T. Logan or . Sjoberg Department of Biochemistry and StructuralBiology Lund University Box 124 S-221 00 Lund Department of Biochemistry of Molecular Biology and Functional Genomics Stockholm University S-106 91 Stockholm Sweden Fax 46 46 222 4692 46 8 16 64 88 Tel 46 46 222 1443 46 8 16 41 50 E-mail britt-marie. sjoberg@ Website http http . Database Structuraldata for oxidized and reduced NrdI are available in the Protein Data Bank under the accession numbers 2XOD and 2XOE Received 12 July 2010 revised 10 August 2010 accepted 18 August 2010 The small flavoprotein NrdI is an essential component of the class Ib ribonucleotide reductase system in many bacteria. NrdI interacts with the class Ib radical generating protein NrdF. It is suggested to be involved in the rescue of inactivated diferric centres or generation of active dimanganese centres in NrdF. Although NrdI bears a superficial resemblance to flavo-doxin its redox properties have been demonstrated to be strikingly different. In particular NrdI is capable of two-electron reduction whereas flavodoxins are exclusively one-electron reductants. This has been suggested to depend on a lesser destabilization of the negatively-charged hydroquinone state than in flavodoxins. We have determined the crystal structures of NrdI from Bacillus anthracis the .

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