TAILIEUCHUNG - Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves

Lipopolysaccharide is a major constituent of the outer membrane of Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as tumor necrosis factor-aand interleukins IL-1b and IL-6. These cytokines appear to be responsible for the neurotoxicity observed in peripheral nervous system inflammatory disease. | ỊFEBS Journal Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves Aiguo Shen1 Junling Yang2 Yangyang Gu3 Dan Zhou4 Linlin Sun2 Yongwei Qin2 Jianping Chen2 Ping Wang2 Feng Xiao2 Li Zhang2 and Chun Cheng1 2 1 Jiangsu Province Key Laboratory of Neuroregeneration Nantong University Jiangsu China 2 Department of Microbiology and Immunology MedicalCollege Nantong University Jiangsu China 3 Department of Surgery RICH Hospital Nantong Jiangsu China 4 Department of Biochemistry MedicalCollege of Nantong University Jiangsu China Keywords intercellular adhesion molecule-1 lipopolysaccharide mitogen-activated protein kinase peripheralnervous system Schwann cell Correspondence C. Cheng Jiangsu Province Key Laboratory of Neurodegeneration Nantong University 19 Qi-xiu Road Nantong Jiangsu 226001 China Fax 86 513 85051999 Tel 86 513 85051999 E-mail cheng_chun@ These authors contributed equally to this work Received 30 April2008 revised 22 June 2008 accepted 27 June 2008 doi Lipopolysaccharide is a major constituent of the outer membrane of Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as tumor necrosis factor-a and interleukins IL-1P and IL-6. These cytokines appear to be responsible for the neurotoxicity observed in peripheral nervous system inflammatory disease. It has been reported that in the central nervous system the expression level of intercellular adhesion molecule-1 ICAM-1 was dramatically upregulated in response to LPS as well as many inflammatory cytokines. ICAM-1 contributes to multiple processes seen in central nervous system inflammatory disease for example migration of leukocytes to inflammatory sites and adhesion of polymorphonuclear cells and monocytes to central nervous system cells. In the present study we found that lipopolysacharide evoked ICAM-1 mRNA and protein expression early at 1 h .

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