TAILIEUCHUNG - Báo cáo y học: "Loss of genes implicated in gastric function during platypus evolution"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Loss of genes implicated in gastric function during platypus evolution. | Open Access Research Loss of genes implicated in gastric function during platypus evolution Gonzalo R Ordonez LaDeana W Hillier Wesley C Warren Frank Grutzner Carlos López-Otín and Xose S Puente Addresses Departamento de Bioquímica y Biología Molecular Facultad de Medicina Instituto Universitario de Oncología Universidad de Oviedo C Fernando Bongera s n 33006 Oviedo Spain. tGenome Sequencing Center Washington University School of Medicine Campus Box 8501 4444 Forest Park Avenue St. Louis Missouri 63108 USA. Discipline of Genetics School of Molecular Biomedical Science The University of Adelaide 5005 South Australia Adelaide Australia. Correspondence Xose S Puente. Email xspuente@ Published 15 May 2008 Genome Biology 2008 9 R81 doi gb-2008-9-5-r8l The electronic version of this article is the complete one and can be found online at http 2008 9 5 R8l Received 16 December 2007 Revised 4 April 2008 Accepted 1 5 May 2008 2008 Ordonez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The duck-billed platypus Ornithorhynchus anatinus belongs to the mammalian subclass Prototheria which diverged from the Theria line early in mammalian evolution. The platypus genome sequence provides a unique opportunity to illuminate some aspects of the biology and evolution of these animals. Results We show that several genes implicated in food digestion in the stomach have been deleted or inactivated in platypus. Comparison with other vertebrate genomes revealed that the main genes implicated in the formation and activity of gastric juice have been lost in platypus. These include the aspartyl proteases pepsinogen A and pepsinogens B C the hydrochloric acid secretion stimulatory hormone .

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