TAILIEUCHUNG - Báo cáo y học: "The rhythms of life"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:The rhythms of life. | Meeting report The rhythms of life Jurgen A Ripperger Address Department of Medicine Unit of Biochemistry University of Fribourg CH-1700 Fribourg Switzerland. Email Published 31 August 2007 Genome Biology 2007 8 313 doi gb-2007-8-8-3l3 The electronic version of this article is the complete one and can be found online at http 2007 8 8 313 2007 BioMed Central Ltd A report on the symposium Clocks and Rhythms Cold Spring Harbor USA 30 May-4 June 2007. Many metabolic and physiological processes occur in a periodic fashion and surprisingly enough many of these rhythms rely on relatively simple biochemical reactions. A recent symposium on biological rhythms held at the Cold Spring Harbor Laboratory was a follow-up to a pioneering symposium held there in 1960 which many people in the field consider as the start of modern chronobiology. This year s symposium not only provided insights into the latest research of circadian rhythms in cyanobacteria Neurospora Drosophila Arabidopsis and mammals but also on metabolic cycles in yeast the segmentation clock in mammals regulation of life span and many more. I will focus here only on some aspects of the meeting. Periodicity in yeast and vertebrate development More than 30 years ago conditions for the culture of baker s yeast were established to allow homeostatic growth. The constant supply of oxygen and nutrients provokes multiple highly synchronized metabolic cycles with a period length of about 40 minutes. These self-sustaining cycles can be separated into three phases an oxidative that is oxygenconsuming phase a reductive building phase and a reductive charging phase. It appears that hydrogen sulfide secretion and clearance are major synchronizers of these processes. Robert Klevecz Beckman Research Institute Duarte USA provided evidence that each phase has its own pattern of gene transcription and that the replication of DNA about 10 of the cells during a cycle

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