TAILIEUCHUNG - Báo cáo khoa học: " Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination | Virology Journal BioMed Central Open Access Short report Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination Arun Ammayappan1 2 Chitra Upadhyay1 Jack Gelb Jr3 and Vikram N Vakharia 1 Address 1Center of Marine Biotechnology University of Maryland Biotechnology Institute Baltimore 701 East Pratt Street Baltimore Maryland 21202-3101 USA 2Department of Veterinary Medicine University of Maryland College Park MD 20742 USA and 3Avian Biosciences Center University of Delaware 531 South College Avenue Newark DE 19716-2150 USA Email Arun Ammayappan - ammayapp@ Chitra Upadhyay - upadhyay@ Jack Gelb - jgelb@ Vikram N Vakharia - vakharia@ Corresponding author Published 22 December 2008 Virology Journal 2008 5 157 doi l743-422X-5-l57 Received 22 September 2008 Accepted 22 December 2008 This article is available from http content 5 l l57 2008 Ammayappan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ An infectious bronchitis virus Arkansas DPI Ark DPI virulent strain was sequenced analyzed and compared with many different IBV strains and coronaviruses. The genome of Ark DPI consists of 27 620 nucleotides excluding poly A tail and comprises ten open reading frames. Comparative sequence analysis of Ark DPI with other IBV strains shows striking similarity to the Conn Gray JMK and Ark 99 which were circulating during that time period. Furthermore comparison of the Ark genome with other coronaviruses demonstrates a close relationship to turkey coronavirus. Among non-structural genes the 5 untranslated region UTR 3C-like .

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