TAILIEUCHUNG - Báo cáo y học: " Iron deficiency in critically ill patients: highlighting the role of hepcidin"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Iron deficiency in critically ill patients: highlighting the role of hepcidin. | Heming et al. Critical Care 2011 15 210 http content 15 2 210 CRITICAL CARE REVIEW L_ Iron deficiency in critically ill patients highlighting the role of hepcidin Nicholas Heming1 Philippe Montravers1 Sigismond Lasocki2 This article is one of eleven reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2011 Springer Verlag and co-published as a series in Critical Care. Other articles in the series can be found online at http series annual. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http series 8901 Introduction Iron is a paradoxical element essential for living organisms but also potentially toxic. Indeed iron has the ability to readily accept and donate electrons interconverting from soluble ferrous form Fe2 to the insoluble ferric form Fe3 . This capacity allows iron to play a major role in oxygen transport as the central part of hemoglobin but also in electron transfer nitrogen fixation or DNA synthesis all essential reactions for living organisms. Indeed iron deficiency is the main cause of anemia 1 as well as a cause of fatigue 2 3 and decreased effort capacity 4 5 . However despite a high frequency of anemia among critically ill patients with 60 to 66 being anemic at intensive care unit ICU admission 6 7 to date little is known about iron deficiency and iron metabolism in critically ill patients 8 . The interaction between inflammation and iron metabolism interferes with the usual iron metabolism variables and renders this metabolism difficult to investigate 9 10 . The recent discovery of hepcidin the master regulator of iron metabolism has shed new light on the regulation of iron homeostasis and has helped our understanding of complex clinical situations such as those observed in critically ill patients where several regulatory circuits interfere with iron metabolism 11 . The purpose of this article is to review iron .

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