TAILIEUCHUNG - Báo cáo y học: "Modular organization in the reductive evolution of protein-protein interaction networks"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Modular organization in the reductive evolution of protein-protein interaction networks. | Open Access Research Modular organization in the reductive evolution of protein-protein interaction networks Javier Tamames Andrés Moya and Alfonso Valencia Addresses Instituto Cavanilles de Biodiversidad y Biología Evolutiva Universitat de València 46071 Valencia Spain. Structural and Computational Biology Programme Spanish National Cancer Research Centre CNIO 28029 Madrid Spain. Correspondence Javier Tamames. Email Published 28 May 2007 Genome Biology 2007 8 R94 doi 186 gb-2007-8-5-r94 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R94 Received 28 July 2006 Revised 30 January 2007 Accepted 28 May 2007 2007 Tamames et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The variation in the sizes of the genomes of distinct life forms remains somewhat puzzling. The organization of proteins into domains and the different mechanisms that regulate gene expression are two factors that potentially increase the capacity of genomes to create more complex systems. High-throughput protein interaction data now make it possible to examine the additional complexity generated by the way that protein interactions are organized. Results We have studied the reduction in genome size of Buchnera compared to its close relative Escherichia coli. In this well defined evolutionary scenario we found that among all the properties of the protein interaction networks it is the organization of networks into modules that seems to be directly related to the evolutionary process of genome reduction. Conclusion In Buchnera the apparently non-random reduction of the modular structure of the networks and the retention of essential .

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