TAILIEUCHUNG - Báo cáo y học: "The fungal frontier"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The fungal frontier. | Meeting report The fungal frontier Jill R Blankenship and Aaron P Mitchell Address Department of Microbiology Columbia University New York NY 10032 USA. Correspondence Aaron P Mitchell. Email apm4@ Published 22 May 2007 Genome Biology 2007 8 305 doi gb-2007-8-5-305 The electronic version of this article is the complete one and can be found online at http 2007 8 5 305 2007 BioMed Central Ltd A report of the 24th Fungal Genetics Conference Asilomar USA 20-25 March 2007. Fungal biology has long provided mechanistic insight into the workings of all eukaryotes and the growing number of sequenced fungal genomes - 56 and counting - is yielding unprecedented views of genome evolution and its sometimes surprising driving forces. New research is uncovering why pathogens are pathogenic how fungi respond to their environment what forces drive the divergence of related species and what processes underlie this evolution. Never was this more apparent than at the fungal genetics conference in Asilomar this March. Phylogeny and evolution of paralogs and gene families The ancestor of Saccharomyces cerevisiae and closely related species underwent a whole-genome duplication event followed by loss of most duplicated regions. Ken Wolfe s group Trinity College Dublin Ireland has found some surprises in the aftermath of the whole-genome duplication from the sequence of Kluyveromyces polysporus. The K. polysporus and S. cerevisiae genomes are similar in size gene number and overall distribution of gene function but the post-duplication loss events in each lineage are different in numerous cases K. polysporus retains the paralog of an S. cerevisiae gene. Interestingly many genes remain duplicated in both species suggesting a considerable selective advantage for their maintenance. Functional relationships between paralogs that date back to the whole-genome duplication have begun to reveal mechanisms of subfunctionalization how duplicated genes evolve .

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