TAILIEUCHUNG - Báo cáo khoa học: Cytokine properties of prokineticins Justin Monnier and Michel Samson

Prokineticins are a novel family of secreted peptides with diverse regulatory roles, one of which is their capacity to modulate immunity in humans and in other species. Prokineticins are small peptides of 8 kDa that mediate their biological activities by signaling through two homologous G-protein-coupled receptors (prokineticin receptor 1 and prokineticin receptor 2). | REVIEW ARTICLE Cytokine properties of prokineticins Justin Monnier and Michel Samson INSERM U620 Université de Rennes 1 IFR 140 Rennes Cedex France Keywords chemokine chemokine receptor cytokine dendritic cells GPCR innate immunity macrophages myeloid cell prokineticin prokineticin receptor Correspondence M. Samson INSERM U620 Universite de Rennes 1 2 avenue du Prof. Leon Bernard 35043 Rennes cedex France Fax 33 02 23 23 47 94 Tel 33 02 23 23 48 06 E-mail Received 26 March 2008 revised 20 May 2008 accepted 17 June 2008 Prokineticins are a novel family of secreted peptides with diverse regulatory roles one of which is their capacity to modulate immunity in humans and in other species. Prokineticins are small peptides of 8 kDa that mediate their biological activities by signaling through two homologous G-protein-coupled receptors prokineticin receptor 1 and prokineticin receptor 2 . This family of peptides is characterized by a completely conserved N-termi-nal hexapeptide crucial for their bioactivities and a unique structural motif comprising five disulfide bonds. Prokineticins and their receptors are highly expressed in bone marrow in peripheral circulating leukocytes in inflamed tissues and in resident organ immune cells. Their structure size signaling and biological activities are reminiscent of the chemokine superfamily. In this review emphasis is placed on the properties of prokineticins as cytokines and their role in the immune system. doi Introduction Prokineticin 1 PROK1 and prokineticin 2 PROK2 otherwise known as endocrine gland vascular endothelial factor EG-VEGF and Bombina variegata 8 Bv8 respectively are a novel family of peptides that are highly conserved across species. Indeed prokineti-cin-like peptides are present in invertebrates crayfish shrimp vertebrates black mamba snake frogs trout fugu and mammals rodents bull humans 1 2 . One of the first biological activities reported was the .

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