TAILIEUCHUNG - Báo cáo khoa học: Protein kinase Ce: function in neurons

Protein kinase Ce is expressed at higher levels in the brain compared to other tissues such as the heart and kidney, suggesting that it plays an important role in the nervous system. Several neural functions of PKCe, including neurotransmitter release and ion channel regulation, have been identified using PKCe knockout mice. | ễFEBS Journal MINIREVIEW Protein kinase Ce function in neurons Yasuhito Shirai Naoko Adachi and Naoaki Saito BiosignalResearch Center Kobe University Japan Keywords alcohol ischemia LTP neurite outgrowth pain Correspondence Y. Shirai Laboratory of Molecular Pharmacology BiosignalResearch Center Kobe 657-8501 Japan Fax 81 78803 5971 Tel 81 78803 5962 E-mail shirai@ Received 26 December 2007 revised 26 May 2008 accepted 16 June 2008 doi Protein kinase Ce is expressed at higher levels in the brain compared to other tissues such as the heart and kidney suggesting that it plays an important role in the nervous system. Several neural functions of PKCe including neurotransmitter release and ion channel regulation have been identified using PKCe knockout mice. In this review we focus on the involvement of protein kinase Ce in neurite outgrowth presynaptic regulation alcohol actions ischemic preconditioning and pain. Expression of PKC- in the brain Northern- and immunoblot analyses of the brain have revealed the predominant presence of protein kinase Ce PKCe mRNA and protein respectively 1 2 the subtype has been cloned from rat brain 3 . Immunohistochemistry of PKCe reveals the most abundant expression of the enzyme in the hippocampus olfactory tubercle and Calleja s islands with moderate expression in the cerebral cortex anterior olfactory nuclei accumbens nucleus lateral septal nuclei and caudate putamen Table 1 . The distribution of PKCe in the brain is consistent with results of in situ hybridization 4 . Interestingly the immunoreactivity of the protein is evident in the nerve fibers and precise observation using electron microscopy reveals its presy-naptic localization 4 5 . These findings suggest the involvement of PKCe in neurite outgrowth and presyn-aptic functions such as neurotransmitter release. As little is known about the role of PKCe in brain development we measured changes in the amount of PKCe protein in the rat .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• breast cancer
• biological activities
• gastric cancer
• medical knowledge
• medical research
• analysis of cytoplasmic
• oxidation
• Crystal structure
• bacteria
• hemoglobin
• medicine
• cell proliferation
• chemical reaction
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine