TAILIEUCHUNG - Báo cáo y học: " Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein | Virology Journal BioMed Central Research Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against Influenza A M2 protein Roger R Beerli 1 Monika Bauer1 Nicole Schmitz1 2 Regula B Buser1 Myriam Gwerder1 3 Simone Muntwiler1 4 Wolfgang A Renner1 Philippe Saudan1 and Martin F Bachmann1 Open Access Address 1Cytos Biotechnology AG Wagistrasse 25 CH-8952 Schlieren Switzerland 2Actelion Pharmaceuticals Ltd Gewerbestrasse 16 4123 Allschwil Switzerland 3GlycoVaxyn AG Grabenstrasse 3 8952 Schlieren Switzerland and 4Biozentrum University of Basel Klingelbergstrasse 50 70 4056 Basel Switzerland Email Roger R Beerli - Monika Bauer - Nicole Schmitz - Regula B Buser - Myriam Gwerder - Simone Muntwiler - Wolfgang A Renner - Philippe Saudan - Martin F Bachmann - Corresponding author Published 21 December 2009 Received 21 October 2009 Accepted 21 December 2009 Virology Journal 2009 6 224 doi I743-422X-6-224 This article is available from http content 6 1 224 2009 Beerli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Influenza virus infection is a prevalent disease in humans. Antibodies against hemagglutinin have been shown to prevent infection and hence hemagglutinin is the major constituent of current vaccines. Antibodies directed against the highly conserved extracellular domain of M2 have also been shown to mediate protection against Influenza A infection in various animal models. Active vaccination is generally considered the best .

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