TAILIEUCHUNG - Báo cáo y học: "Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts | Virology Journal BioMed Central Research Human herpesvirus 6 envelope components enriched in lipid rafts evidence for virion-associated lipid rafts Akiko Kawabata1 Huamin Tang1 Honglan Huang3 Koichi Yamanishi1 and Yasuko Mori 1 2 Address laboratory of Virology and Vaccinology Division of Biomedical Research National Institute of Biomedical Innovation 7-6-8 Saito-Asagi Ibaraki Osaka 567-0085 Japan 2Division of Clinical Virology Kobe University Graduate School of medicine 7-5-1 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan and 3Department of Pathogenobiology School of Basic Medical Sciences Jilin University Changchun 130021 PR China Email Akiko Kawabata - akawabata@ Huamin Tang - thm@ Honglan Huang - ymori@ Koichi Yamanishi - yamanishi@ Yasuko Mori - ymori@ Corresponding author Open Access Published 19 August 2009 Received I June 2009 Accepted 19 August 2009 Virology Journal 2009 6 127 doi 1743-422X-6-127 This article is available from http content 6 1 127 2009 Kawabata et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In general enveloped viruses are highly dependent on their lipid envelope for entry into host cells. Here we demonstrated that during the course of virus maturation a significant proportion of human herpesvirus 6 HHV-6 envelope proteins were selectively concentrated in the detergentresistant glycosphingolipid- and cholesterol-rich membranes rafts in HHV-6-infected cells. In addition the ganglioside GM1 which is known to partition preferentially into lipid rafts was detected in purified virions along with viral envelope glycoproteins gH gL gB .

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