TAILIEUCHUNG - Báo cáo y học: "Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008 | Huang et al. Virology Journal 2010 http content 7 1 277 VIROLOGY JOURNAL RESEARCH Open Access Genetic diversity and C2-like subgenogroup strains of enterovirus 71 Taiwan 2008 1 t 1 t 1 1 1 1 1 Yuan-Pin Huang Tsuey-Li Lin Li-Ching Hsu Yu-Ju Chen Yin-Hsin Tseng Chiu-Chu Hsu Wen-Bin Fan Jyh-Yuan Yang1 Feng-Yee Chang1 Ho-Sheng Wu1 2 Abstract Background Human enterovirus 71 EV-71 is known of having caused numerous outbreaks of hand-foot-mouth disease and other clinical manifestations globally. In 2008 989 EV-71 strains were isolated in Taiwan. Results In this study the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted which includes 3 previously reported subgenogroups of C5 B5 and C4 and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched. Conclusions Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future. Background Belonging to the genus Enterovirus of the family Picor-naviridae human enterovirus 71 EV-71 is one of the most causative pathogens infecting humans and may cause outbreaks of hand-foot-mouth disease HFMD herpangina and severe neurological symptoms especially in young children 1 . There are over one hundred serotypes identified in the genus Enterovirus 2 which was originally classified into polioviruses coxsackievirus A coxsackievirus B and .

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