TAILIEUCHUNG - Báo cáo y học: " The pathogenesis of low pathogenicity H7 avian influenza viruses in chickens, ducks and turkeys"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The pathogenesis of low pathogenicity H7 avian influenza viruses in chickens, ducks and turkeys | Spackman et al. Virology Journal 2010 7 331 http content 7 1 331 VIROLOGY JOURNAL RESEARCH Open Access The pathogenesis of low pathogenicity H7 avian influenza viruses in chickens ducks and turkeys 1 2 2 2 2 1 Erica Spackman Jack Gelb Jr Lauren A Preskenis Brian S Ladman Conrad R Pope Mary J Pantin-Jackwood Enid T Mckinley1 Abstract Background Avian influenza AI viruses infect numerous avian species and low pathogenicity LP AI viruses of the H7 subtype are typically reported to produce mild or subclinical infections in both wild aquatic birds and domestic poultry. However relatively little work has been done to compare LPAI viruses from different avian species for their ability to cause disease in domestic poultry under the same conditions. In this study twelve H7 LPAI virus isolates from North America were each evaluated for their comparative pathogenesis in chickens ducks and turkeys. Results All 12 isolates were able to infect all three species at a dose of 106 50 egg infectious doses based on seroconversion although not all animals seroconverted with each isolate-species combination. The severity of disease varied among isolate and species combinations but there was a consistent trend for clinical disease to be most severe in turkeys where all 12 isolates induced disease and mortality was observed in turkeys exposed to 9 of the 12 viruses. Turkeys also shed virus by the oral and cloacal routes at significantly higher titers than either ducks or chickens at numerous time points. Only 3 isolates induced observable clinical disease in ducks and only 6 isolates induced disease in chickens which was generally very mild and did not result in mortality. Full genome sequence was completed for all 12 isolates and some isolates did have features consistent with adaptation to poultry . NA stalk deletions however none of these features correlated with disease severity. Conclusions The data suggests that turkeys may be more susceptible to clinical .

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