TAILIEUCHUNG - báo cáo khoa học:" Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS) | Twiss et al. Health and Quality of Life Outcomes 2010 8 117 http content 8 1 117 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Interpreting scores on multiple sclerosis-specific patient reported outcome measures the PRIMUS and U-FIS 1 1 1 2 James Twiss Lynda C Doward Stephen P McKenna Benjamin Eckert Abstract Background The PRIMUS is a Multiple Sclerosis MS -specific suite of outcome measures including assessments of QoL PRIMUS QoL scored 0-22 and activity limitations PRIMUS Activities scored 0-30 . The U-FIS is a measure of fatigue impact scored 0-66 . These measures have been fully validated previously using an MS sample with mixed diagnoses. The aim of the present study was to validate the measures further in a specifically Relapse Remitting MS RRMS sample and to provide preliminary evidence of the responder definitions RD also known as minimal important difference for these instruments. Methods Data were derived from a multi-country efficacy trial of MS patients with assessments at baseline and 12 months. Baseline data were used to assess the internal reliability and validity of the measures. Both anchorbased and distribution-based approaches were employed for estimating RD. Anchor-based estimates were based on published RD values for the EQ-5D and were assessed for those improving and deteriorating separately. Distribution-based estimates were based on standard error of measurement SEM change score equivalent to and change score equivalent to effect sizes ES . Results The sample included 911 RRMS patients female age mean SD years duration of MS mean SD years . Results showed that the PRIMUS and U-FIS had good internal consistency. Appropriate correlations were observed with comparator instruments and both measures were able to distinguish between participants based on Expanded Disability Status Scale scores and time since diagnosis. The anchor-based and distribution-based RD estimates were PRIMUS .

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