TAILIEUCHUNG - báo cáo khoa học:" Multimorbidity and health-related quality of life in the older population: results from the German KORA-Age study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Multimorbidity and health-related quality of life in the older population: results from the German KORA-Age study | Hunger et al. Health and Quality of Life Outcomes 2011 9 53 http content 9 1 53 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Multimorbidity and health-related quality of life in the older population results from the German KORA-Age study 1 2 1 2 1 2 Matthias Hunger Barbara Thorand Michaela Schunk Angela Doring Petra Menn Annette Peters and Rolf Holle1 Abstract Background Multimorbidity in the older population is well acknowledged to negatively affect health-related quality of life HRQL . Several studies have examined the independent effects of single diseases however little research has focused on interaction between diseases. The purpose of this study was to assess the impact of six self-reported major conditions and their combinations on HRQL measured by the EQ-5D. Methods The EQ-5D was administered in the population-based KORA-Age study of 4 565 Germans aged 65 years or older. A generalised additive regression model was used to assess the effects of chronic conditions on HRQL and to account for the nonlinear associations with age and body mass index BMI . Disease interactions were identified by a forward variable selection method. Results The conditions with the greatest negative impact on the EQ-5D index were the history of a stroke regression coefficient p and chronic bronchitis regression coefficient p . Patients with both diabetes and coronary disorders showed more impaired HRQL than could be expected from their separate effects coefficient of interaction term p . A synergistic effect on HRQL was also found for the combination of coronary disorders and stroke. The effect of BMI on the mean EQ-5D index was inverse U-shaped with a maximum at around kg m2. Conclusions There are important interactions between coronary problems diabetes mellitus and the history of a stroke that negatively affect HRQL in the older German population. Not only high but also low BMI is associated with impairments in .

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