TAILIEUCHUNG - báo cáo khoa học:" Administration of bisphosphonate for hypercalcemia associated with oral cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Administration of bisphosphonate for hypercalcemia associated with oral cancer | Head Face Medicine BioMed Central Research Open Access Administration of bisphosphonate for hypercalcemia associated with oral cancer Kojiro Onizawa and Hiroshi Yoshida Address Oral and Maxillofacial Surgery Doctoral Program in Functional and Regulatory Medical Sciences Graduate School of Comprehensive Human Sciences University of Tsukuba Japan Email Kojiro Onizawa - k-oni@ Hiroshi Yoshida - hyoshida@ Corresponding author Published 10 April 2006 Received 13 January 2006 Head Face Medicine2006 2 9 doi 1746-160X-2-9 Accepted 10 April 2006 This article is available from http content 2 1 9 2006Onizawa and Yoshida licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The efficacy of treating hypercalcemia with bisphosphonate BP in patients with advanced oral cancer has not been fully investigated. This retrospective study evaluated the clinical course of hypercalcemic patients with and without BP treatment. Methods Sixteen hypercalcemic patients most of whom had uncontrollable locoregional lesions and lung metastases were studied. Nine patients had been given BP and the rest had not. Results There were significant differences in age and serum ALT between the BP-treated and -untreated groups. The first administration of BP effectively and safely decreased the serum calcium level but repeated administrations were less effective. Although the patients treated with BP survived significantly longer than the untreated subjects the difference of the median was only about 2 weeks. Conclusion The occurrence of hypercalcemia in oral cancer patients apparently implies an extremely poor prognosis and long-term survival cannot be expected even with BP treatment. .

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