TAILIEUCHUNG - Báo cáo y học: " Determining relevant cortisol concentrations in critically ill patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Determining relevant cortisol concentrations in critically ill patients. | Manji and Kumar Critical Care 2010 14 113 http content 14 1 113 CRITICAL CARE COMMENTARY L__ Determining relevant cortisol concentrations in critically ill patients Rizwan A Manji and Anand Kumar See related research by Cohen etal. http content 13 6 R189 Abstract The importance of adrenal function to survival in critically ill patients has been established however identifying the best method to diagnose adrenal insufficiency has been problematic. Multiple methods of determining adrenal function have been developed each with its advantages and disadvantages. Serum-free cortisol levels are probably the most accurate although obtaining this result is technically demanding. Cohen and colleagues investigated the feasibility of measuring tissue cortisol levels in burn patients and whether tissue cortisol levels could be used as a surrogate for plasma-free cortisol levels. In the previous issue of Critical Care Cohen and colleagues 1 conducted a feasibility study and examined 10 burn patients and 3 healthy volunteers to determine whether there were correlations between tissue cortisol levels and plasma-free cortisol levels. The authors hypothesized that tissue cortisol levels are more relevant as this is what binds to cellular cortisol receptors and leads to cortisol-associated physiological changes seen. The authors concluded that obtaining tissue cortisol levels was feasible but there was no correlation between tissue and plasma cortisol levels. Different methods of measuring cortisol levels are used. The most commonly used method measures total serum cortisol which is free and protein transcortin and albumin -bound cortisol. Measuring total cortisol has poor sensitivity and specificity and high variability in critically ill patients 2 . In addition the immunoassays used to determine total cortisol are subject to interference with heterophile antibodies present in some critically ill patients 3 . Using mass spectroscopy to Correspondence

TỪ KHÓA LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.