TAILIEUCHUNG - Báo cáo y học: " Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province, China"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province, China | Tang et al. Virology Journal 2011 8 23 http content 8 1 23 J VIROLOGY JOURNAL RESEARCH Open Access Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province China Liuying TangH Li Wang2t Xiaojuan Tan1 Wenbo Xu1 Abstract Background Pneumonia caused by adenovirus infection is usually severe especially with adenovirus serotype 7 commonly associated with lower respiratory tract disease outbreaks. We reported an outbreak of 70 cases of severe pneumonia with one death of infants in Shaanxi Province China. Sampling showed adenovirus 7 Ad7 as the primary pathogen with some co-infections. Results Two strains of adenovirus and two strains of enterovirus were isolated the 21 pharynx swabs showed 14 positive amplifications for adenovirus three co-infections with respiratory syncytial virus two positive for rhinovirus one positive for parainfluenza 3 and four negative. Adenovirus typing showed nine of the nine adenovirus positive samples were HAdV-7 three were HAdV-3 and two were too weak to perform sequencing. The entire hexon gene of adenovirus was sequenced and analyzed for the two adenovirus serotype 7 isolates showing the nucleic acid homology was between the two strains and compared to the reference strain HAdV-7 GenBank accession number AY769946 . For the 21 acute phase serum samples from the 21 patients six samples had positives results for ELISA detection of HAdV IgA and the neutralization titers of the convalescent-phase samples were four times higher than those of the acute-phase samples in nine pairs. Conclusions We concluded adenovirus was the viral pathogen primarily HAdV-7 with some co-infections responsible for the outbreak. This is the first report of an infant pneumonia outbreak caused by adenovirus serotype 7 in Shaanxi Province China. Background Human adenoviruses cause a wide spectrum of diseases. Pneumonia caused by adenovirus infection is usually severe especially .

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