TAILIEUCHUNG - Báo cáo y học: " Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report | Journal of Medical Case Reports BioMed Central Open Access Neurological presentation of Whipple s disease after long-term antibiotic treatment a case report Felix Gundling 1 2 Henning Wittenburg2 Andrea Tannapfel3 and Joachim Mossner2 Address 1Second Department of Medicine Bogenhausen Hospital Academic Teaching Hospital Technical University of Munich Munich Germany 2Second Department of Medicine University of Leipzig Leipzig Germany and 3Department for Pathology University of Leipzig Leipzig Germany Email Felix Gundling - HenningWittenburg-witth@ AndreaTannapfel - Joachim Mossner - Moej@ Corresponding author Published 3 June 2008 Received 2 September 2007 Journal of Medical Case Reports 2008 2 191 doi 1752-1947-2-191 Accepted 3 June 2008 This article is available from http content 2 1 191 2008 Gundling et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Introduction Whipple s disease is a rare systemic infectious disorder caused by Tropheryma whipplei. Case presentation We report a 68-year-old male with Whipple s disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset. Conclusion The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple s disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative. Introduction Whipple s disease WD is a rare condition caused by infection with Gram-positive bacilli Tropheryma

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