TAILIEUCHUNG - Mechanism of Eukaryotic Homologous Recombination

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I. As such, HR is indispensable for the maintenance of genome integrity and the avoidance of cancers in humans. The HR reaction is mediated by a conserved class of enzymes termed recombinases. | Annu. Rev. Biochem. 229-257. Downloaded from by NEW YORK UNIVERSITY - BOBST LIBRARY on 07 02 08. For personal use only. CAR Further Click here for quick links to Annual Reviews content online including Other articles in this volume Top cited articles Top downloaded articles AR s comprehensive search Annu. Rev. Biochem. 2008. 77 229-57 First published online as a Review in Advance on February 14 2008 The Annual Review of Biochemistry is online at This article s doi Copyright 2008 by Annual Reviews. All rights reserved 0066-4154 08 0707-0229 Mechanism of Eukaryotic Homologous Recombination Joseph San Filippo 1 Patrick Sung 1 and Hannah Klein2 department of Molecular Biophysics and Biochemistry Yale University School of Medicine New Haven Connecticut 06520 email 2 Department of Biochemistry and Kaplan Comprehensive Cancer Institute New York University School of Medicine New York New York 10016 email Keywords DNA motor proteins genome maintenance meiosis recombinases recombination mediators Abstract Homologous recombination HR serves to eliminate deleterious lesions such as double-stranded breaks and interstrand crosslinks from chromosomes. HR is also critical for the preservation of replication forks for telomere maintenance and chromosome segregation in meiosis I. As such HR is indispensable for the maintenance of genome integrity and the avoidance of cancers in humans. The HR reaction is mediated by a conserved class of enzymes termed recombinases. Two recombinases Rad51 and Dmc1 catalyze the pairing and shuffling of homologous DNA sequences in eukaryotic cells via a filamentous intermediate on ssDNA called the presynaptic filament. The assembly of the presynaptic filament is a rate-limiting process that is enhanced by recombination mediators such as the breast tumor suppressor BRCA2. HR accessory factors that .

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