TAILIEUCHUNG - Báo cáo y học: "Clinical review: RIFLE and AKIN – time for reappraisal"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: RIFLE and AKIN – time for reappraisal. | Available online http content 13 3 211 Review Clinical review RIFLE and AKIN - time for reappraisal Dinna N Cruz1 2 Zaccaria Ricci3 and Claudio Ronco1 2 1 Department of Nephrology Ospedale San Bortolo Viale Rodolfi 37 36100 Vicenza Italy international Renal Research Institute Vicenza Viale Rodolfi 37 36100 Vicenza Italy 3Department of Pediatric Cardiosurgery Bambino Gesù Hospital Piazza San Onofrio 4 00100 Rome Italy Corresponding author Dinna N Cruz dinnacruzmd@ Published 25 June 2009 This article is online at http content 13 3 211 2009 BioMed Central Ltd Critical Care 2009 13 211 doi cc7759 Abstract In recent years the use of the consensus definitions of acute kidney injury RIFLE and AKIN in the literature has increased substantially. This indicates a highly encouraging acceptance by the medical community of a unifying definition for acute kidney injury. This is a very important and positive step in the right direction. There remains some variation in how the criteria are interpreted and used in the literature including use nonuse of urine output criteria use of change in estimated glomerular filtration rate rather than change in creatinine and choice of baseline creatinine. The present review is intended to aid the reader in critically appraising studies using these consensus definitions. Since no single definition will be perfect a logical next step would be to reconcile existing definitions moving the medical community towards using a single consensus definition as has been done with sepsis and acute lung injury acute respiratory distress syndrome. As new data emerge integration of novel biomarkers into the consensus definition will be a welcome refinement. Introduction Acute kidney injury AKI is an important clinical issue especially in the critical care setting. AKI has been shown in multiple studies to be a key independent risk factor for mortality even after adjustment for demographics severity of illness and other

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