TAILIEUCHUNG - Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish

A plethora of corroborative genetic studies led to the view that, across the animal kingdom, the gene-regulatory cascades triggering sexual develop-ment bear little resemblance to each other. As a result, the common emerg-ing picture is that the genes at the top of the cascade are not conserved | IFEBS Journal MINIREVIEW Dmrtl genes at the crossroads a widespread and central class of sexual development factors in fish Amaury Herpin and Manfred Schartl PhysiologicalChemistry I University of Wuerzburg Germany Keywords Dmrt1bY Evolution Gonad Ovary Sex determination Sex differentiation Steroid hormones Teleost Testis transcriptional regulation Correspondence A. Herpin University of Wuerzburg PhysiologicalChemistry Am Hubland D-97074 Wuerzburg Germany Fax 49 931 888 4150 Tel 49 0 931 888 4153 E-mail Received 5 August 2010 revised 8 December 2010 accepted 25 January 2011 doi A plethora of corroborative genetic studies led to the view that across the animal kingdom the gene-regulatory cascades triggering sexual development bear little resemblance to each other. As a result the common emerging picture is that the genes at the top of the cascade are not conserved whereas the downstream genes have homologues in a much broader spectrum of species. Among these downstream effectors a gene family involved in sex differentiation in organisms as phylogenetically divergent as corals Caenorhabditis elegans Drosophila frogs fish birds and mammals is the dmrt gene family. Despite the attention that Dmrt1 factors have received to date it has not been elucidated how Dmrt1s mediate their activities and putative downstream targets have yet to be characterized. However a remarkable amount of descriptive expression data has been gathered in a large variety of fish particularly with respect to early gonadal differentiation and sex change. This minireview aims at distilling the current knowledge of fish dmrtls in terms of expression and regulation. It is shown how gonadal identities correlate with dimorphic dmrtl expression in gonochoris-tic and hermaphroditic fish species. It is also described how sex steroid hormones affect gonadal identity and dmrtl expression. Emphasis is also given to recent findings .

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