TAILIEUCHUNG - Báo cáo khoa học: Natriuretic peptide system: an overview of studies using genetically engineered animal models

The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Exam-ination of genetically engineered animal models has suggested the signifi-cance of the natriuretic peptide system in cardiovascular, renal and skeletal homeostasis. | IFEBS Journal MINIREVIEW Natriuretic peptide system an overview of studies using genetically engineered animal models Ichiro Kishimoto1 2 Takeshi Tokudome1 Kazuwa Nakao3 and Kenji Kangawa1 1 Department of Biochemistry NationalCerebraland Cardiovascular Center Research Institute Osaka Japan 2 Department of Endocrinology and Metabolism NationalCerebraland Cardiovascular Center Osaka Japan 3 Department of Medicine and ClinicalScience Kyoto University Graduate Schoolof Medicine Japan Keywords bone cardiac hypertrophy guanylylcyclase hypertension natriuretic peptide Correspondence I. Kishimoto Department of Biochemistry NationalCerebraland Cardiovascular Center Research Institute 5-7-1 Fujishiro-dai Suita Osaka 565-8565 Japan Fax 81 6 6835 5402 Tel 81 6 6833 5012 E-mail kishimot@ Received 16 August 2010 revised 11 March 2011 accepted 1 April 2011 doi The mammalian natriuretic peptide system consisting of at least three ligands and three receptors plays critical roles in health and disease. Examination of genetically engineered animal models has suggested the significance of the natriuretic peptide system in cardiovascular renal and skeletal homeostasis. The present review focuses on the in vivo roles of the natriuretic peptide system as demonstrated in transgenic and knockout animal models. Natriuretic peptides The existence of an atrial factor with diuretic and natriuretic activities has been postulated since 1981 1 . In 1983-1984 the isolation and purification of such a factor and determination of its amino acid sequence were accomplished in rats and humans 2-7 . The factor is a peptide distributed mainly in the right and left cardiac atria within granules of myocytes and thus called atrial natriuretic factor or atrial natriuretic peptide ANP . The discovery of ANP revealed that the heart is not only a mechanical pump driving the circulation of blood but also an endocrine organ regulating the cardiovascular-renal system. .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.