TAILIEUCHUNG - Báo cáo y học: "Effects of a multi-herbal extract on type 2 diabete"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of a multi-herbal extract on type 2 diabetes. | Yeo et al. Chinese Medicine 2011 6 10 http content 6 1 10 CHINESE MEDICINE RESEARCH Open Access Effects of a multi-herbal extract on type 2 diabetes Jiyoung Yeo Young-Mi Kang Su-In Cho Myeong-Ho Jung Abstract Background An aqueous extract of multi-hypoglycemic herbs of Panax ginseng Pueraria lobata Dioscorea batatas Decaisne Rehmannia glutinosa Amomum cadamomum Linné Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models. Methods Activities of PPARg agonist anti-inflammation AMPK activator and anti-ER stress were measured in cell models and in db db mice a genetic animal model for type 2 diabetes . Results While the extract stimulated PPARg-dependent luciferase activity and activated AMPK in C2C12 cells it inhibited TNF-a-stimulated IKKp NFkB signaling and attenuated ER stress in HepG2 cells. The db db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels improved postprandial glucose levels enhanced insulin sensitivity and significantly decreased plasma free fatty acid triglyceride and total cholesterol. Conclusion The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models. Background Caused by complex interactions of multiple factors diabetes mellitus type 2 type 2 diabetes is characterized by decreased secretion of insulin by the pancreas and resistance to the action of insulin in various tissues eg muscle liver adipose leading to impaired glucose uptake 1 . Management of type 2 diabetes usually begins with change of diet and exercise 2 and most patients ultimately require pharmacotherapy such as oral anti-diabetic drug OAD 1 . OADs include sulfonylurea non-sulfonylurea secretagogues biguanides eg metformin thiazolidinediones eg TZD or glitazone and glucosidase inhibitors and glucagon-like peptide-1 GLP-1 inhibitor. All OADs however have adverse effects

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