TAILIEUCHUNG - Báo cáo khoa học: MicroRNAs and epigenetics

MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene expression post-transcriptionally. Recent studies have demon-strated that epigenetic mechanisms, including DNA methylation and his-tone modification, not only regulate the expression of protein-encoding genes, but also miRNAs, such as let-7a, miR-9, miR-34a, miR-124, miR-137, miR-148 and miR-203. | IFEBS Journal MINIREVIEW MicroRNAs and epigenetics Fumiaki Sato1 Soken Tsuchiya1 Stephen J. Meltzer2 and Kazuharu Shimizu1 1 Department of Nanobio Drug Discovery Graduate Schoolof PharmaceuticalSciences Kyoto University Japan 2 Division of Gastroenterology and Hepatology Department of Medicine Johns Hopkins University Schoolof Medicine Baltimore MD USA Keywords DNA methylation epigenetics histone modification microRNA Correspondence F. Sato Department of Nanobio Drug Discovery Graduate School of PharmaceuticalSciences Kyoto University 46-29 Shimoadachicho Yoshida Sakyoku Main Building A320 Kyoto 606-8501 Kyoto Japan Fax 81 75 753 9557 Tel 81 75 753 9559 E-mail fsato@ Received 10 November 2010 revised 6 February 2011 accepted 1 March 2011 doi MicroRNAs miRNAs comprise species of short noncoding RNA that regulate gene expression post-transcriptionally. Recent studies have demonstrated that epigenetic mechanisms including DNA methylation and histone modification not only regulate the expression of protein-encoding genes but also miRNAs such as let-7a miR-9 miR-34a miR-124 miR-137 miR-148 and miR-203. Conversely another subset of miRNAs controls the expression of important epigenetic regulators including DNA methyltransferases histone deacetylases and polycomb group genes. This complicated network of feedback between miRNAs and epigenetic pathways appears to form an epigenetics-miRNA regulatory circuit and to organize the whole gene expression profile. When this regulatory circuit is disrupted normal physiological functions are interfered with contributing to various disease processes. The present minireview details recent discoveries involving the epigenetics-miRNA regulatory circuit suggesting possible biological insights into gene-regulatory mechanisms that may underlie a variety of diseases. Introduction MicroRNAs miRNA comprise a class of short noncoding RNAs with 18-25 nucleotides in length that are found in .

• Báo cáo khoa học
• Scientific reports
• scientific research
• Structural biochemistry
• epigenetics
• MicroRNAs
• scientific research
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes