TAILIEUCHUNG - Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy

It is becoming increasingly clear that signals generated in tumor microenvi-ronments are crucial to tumor cell behavior, such as survival, progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites and to localize to distant organs. | IFEBS Journal MINIREVIEW Hyaluronan-CD44 interactions as potential targets for cancer therapy QI I n i i l liQt i51 I I o I d I n 2 i nront C I I u Q r u 113 M I lz c ịố l ara m an AC4 K1 K -XC l un duliQ2 ouilltl IVlioia ralaokeVI Heidin VIIIUeilL C. Hasuail NikOo K. IXalalllallOo SpyiOo S. OkallUallo Roger R. Markwald1 and Shlbnath Ghatak1 1 Regenerative Medicine and CellBiology MedicalUniversity of South Carolina Charleston SC USA 2 Ludwig Institute for Cancer Research Uppsala University BiomedicalCentre Sweden 3 Department of BiomedicalEngineering ND20 Cleveland Clinic Cleveland OH USA 4 Department of Chemistry Laboratory of Biochemistry University of Patras Greece Keywords cancer CD44-varient gene-therapy hyaluronan nanoparticles stem cells shRNA-therapy tumorigenesis tumorstroma wound-healing Correspondence S. Misra or S. Ghatak Regenerative Medicine and CellBiology BSB 613 MedicalUniversity of South Carolina Charleston SC 29425 USA Fax 843 792 0664 Tel 843 792 8642 E-mail misra@ ghatak@ P. Heldin Ludwig Institute for Cancer Research Uppsala University Biomedical Centre Box 595 SE-75124 Uppsala Sweden Tel 0046 18 160414 Fax 0046 18 160420 Received 19 October 2010 revised 18 January 2011 accepted 25 February 2011 doi It is becoming increasingly clear that signals generated in tumor microenvironments are crucial to tumor cell behavior such as survival progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properties to detach from their original sites and to localize to distant organs. CD44 an adhe-sion homing molecule is a major receptor for the glycosaminoglycan hyaluronan which is one of the major components of the tumor extracellular matrix. CD44 a multistructural and multifunctional molecule detects changes in extracellular matrix components and thus is well positioned to provide appropriate responses to changes in the .

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