TAILIEUCHUNG - Báo cáo y học: "Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant. | Comparative Hepatology BioMed Central Case Report Open Access Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant Vlad Ratziu 1 Vincent Thibault2 Yves Benhamou1 and Thierry Poynard1 Address 1 Service d Hépatogastroenterologie Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie Paris France and 2Laboratoire de Virologie Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie Paris France Email Vlad Ratziu - vratziu@ Vincent Thibault - Yves Benhamou - ybenhamou@ Thierry Poynard - tpoynard@ Corresponding author Published II January 2006 Received 01 September 2005 - _ r I I I- I Accepted 1 1 January 2006 Comparative Hepatology 2006 5 1 doi 1476-5926-5-1 This article is available from http content 5 1 1 2006 Ratziu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Prolonged adefovir therapy exposes to the emergence of adefovir resistant hepatitis B virus mutants. Initial reports of the rtN236T mutation showed preserved sensitivity to lamivudine however complex mutations are emerging with reduced susceptibility to lamivudine. Case presentation After 2 years of therapy a cirrhotic patient developed the rtN236T and rtA181T adefovir resistant mutations. He had been previously treated with lamivudine developed lamivudine resistance and despite good compliance had an incomplete response to adefovir. Adefovir resistance resulted in viral breakthrough with hepatitis flare-up and liver decompensation. Tenofovir had an excellent antiviral effect allowing sustained control of viral replication and reversal of hepatic failure. .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.