TAILIEUCHUNG - Báo cáo y học: "Successful pregnancy in pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Successful pregnancy in pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Successful pregnancy in pulmonary arterial hypertension associated with systemic lupus erythematosus a case report Michael Streit Rudolf Speich Manuel Fischler and Silvia Ulrich Address Department of Internal Medicine University Hospital of Zurich Raemistrasse 100 8091 Zurich Switzerland Email MS - RS - MF - SU - Corresponding author Received 19 August 2008 Accepted 23 January 2009 Published 9 June 2009 Journal ofMedical Case Reports 2009 3 7255 doi 1752-1947-3-7255 This article is available from http jmedicalcasereports article view 7255 2009 Streit et al licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Pulmonary arterial hypertension is a complication of systemic lupus erythematosus. Mortality in pregnant patients with pulmonary arterial hypertension related to connective tissue disease is as high as 56 . The authors report the first case of a successful maternal-fetal outcome in a pregnant patient with systemic lupus erythematosus-associated pulmonary arterial hypertension treated with sildenafil and inhaled iloprost during pregnancy and until several weeks after caesarean section. Case presentation The case presented is of a 29-year-old woman with systemic lupus erythematosus and associated severe pulmonary arterial hypertension. Vasodilator therapy with bosentan and sildenafil immunosuppressive therapy with prednisone hydroxychloroquine and azathioprine and oral anticoagulation phenprocoumon had normalized her right ventricular over right atrial pressure when she was diagnosed in her 5th week of pregnancy. The teratogenic .

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