TAILIEUCHUNG - Chapter 017. Fever and Hyperthermia (Part 6)

Regimens for the Treatment of Fever The objectives in treating fever are first to reduce the elevated hypothalamic set point and second to facilitate heat loss. Reducing fever with antipyretics also reduces systemic symptoms of headache, myalgias, and arthralgias. Oral aspirin and NSAIDs effectively reduce fever but can adversely affect platelets and the gastrointestinal tract. Therefore, acetaminophen is preferred to all of these agents as an antipyretic. In children, acetaminophen must be used because aspirin increases the risk of Reye's syndrome. If the patient cannot take oral antipyretics, parenteral preparations of NSAIDs and rectal suppository preparations of various antipyretics can be. | Chapter 017. Fever and Hyperthermia Part 6 Regimens for the Treatment of Fever The objectives in treating fever are first to reduce the elevated hypothalamic set point and second to facilitate heat loss. Reducing fever with antipyretics also reduces systemic symptoms of headache myalgias and arthralgias. Oral aspirin and NSAIDs effectively reduce fever but can adversely affect platelets and the gastrointestinal tract. Therefore acetaminophen is preferred to all of these agents as an antipyretic. In children acetaminophen must be used because aspirin increases the risk of Reye s syndrome. If the patient cannot take oral antipyretics parenteral preparations of NSAIDs and rectal suppository preparations of various antipyretics can be of fever in some patients is highly recommended. Fever increases the demand for oxygen . for every increase of 1 C over 37 C there is a 13 increase in oxygen consumption and can aggravate preexisting cardiac cerebrovascular or pulmonary insufficiency. Elevated temperature can induce mental changes in patients with organic brain disease. Children with a history of febrile or nonfebrile seizure should be aggressively treated to reduce fever although it is unclear what triggers the febrile seizure and there is no correlation between absolute temperature elevation and onset of a febrile seizure in susceptible hyperpyrexia the use of cooling blankets facilitates the reduction of temperature however cooling blankets should not be used without oral antipyretics. In hyperpyretic patients with CNS disease or trauma reducing core temperature mitigates the ill effects of high temperature on the brain. Treating Hyperthermia A high core temperature in a patient with an appropriate history . environmental heat exposure or treatment with anticholinergic or neuroleptic drugs tricyclic antidepressants succinylcholine or halothane along with appropriate clinical findings dry skin hallucinations delirium pupil dilation .

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