TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 153

Pharmaceutical Substances Syntheses, Patents, Applications - Part 153. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Oxitefonium bromide O 1521 Oxitefonium bromide atc A03AB Use anticholinergic antispasmodic RN 17692-63-6 MF CIyH26BrNO3S MW EINECS 241-688-4 LD5 mg kg M . 1050 mg kg M . CN A A-diethyl-2- hydroKyphenyl-2-thienylacetyl oxy -N-methylethanaminium bromide 0 AIClj phenylmagnesium 2-thienylglyoxylic acid ethyl ester bromide thiophene ethoxalyl chloride a-hydroxy-a-phenyl-2-thiopheneacetic acid ethyl ester I OH ----- a-hydroxy-a-phenyl-2 thiophereocetic acid r ci H3CxX CHj ----------------- 2-diethylamino- ethyl chloride H3C Br a-hydroxy-a-phenyl-2-thiophene- methyl acetic ocid 2-diethylamino- bromide ethyl ester II Reference s US 2 541 024 F. F. Blicke 1951 prior. 1946 . Blicke EE Tsao . J. Am. Chem. Soc. JACSAT 66 1645 1944 . Trade Name s F Bismutran ISH -comb. wfm Nibitor ISH wfm Védrénan ISH -comb. wfm Oxitriptan 5-Hydroxy-L-tryptophan Oxytriptanum ATC N06AB Use antidepressant psysiological serotonin precursor RN. 4350-09-8 MF CnH12N2O3 MW EINECS 224-411-1 LD50 375 mg kg M . 1708 mg kg M . 27 mg kg R . 243 mg kg R . CN 5-hydroxy-L-tryptophan 1522 o Oxitriptan 5-benzylaxy-DL-tryptophon 0 ch2 ÇH-Ï .u J dioxone H90 hn ---------- - ch3 5-benzy oxygromìne I 5-benzyloxyindole H3C- O o o CH HN. _ CHO NoOH diethyl formomido-malonote II 1. N00H h20. a 2. HCI 0 H -N nh2 COOH 5-benzyloxy-DL-tryptophon ni acrolein diethyl ocetamido- rCH3 0 0 ọ. OHC X CH -----NH J o ọ kCHj IV moionote N-ocetyl-5-benzyloxy-DL-tryptophan Oxitriptan O 1523 Q opticol resolution III benzyl chloroformote 1. quinine 2. froctionol crystollizotion of the quinine solts 3. HCI extraction with ethyl ocetote -----------------------------L---------------------- vn microbiological oxidation of L-tryptophon L-tryptophon Bacillus subtìlis ATCC 21733 ----------------- --------------- Oxitripton microbiological coupling with tryptophanose producing strains Proteus morganii IFO 3848 or - Erwinia herbicola ATCC 21433 or Ql NHn Enterobacter cloaca ATCC 7256 .

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