TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 147

Pharmaceutical Substances Syntheses, Patents, Applications - Part 147. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Norethandrolone N 1461 Norethandroỉone ATC A14AA09 Use anabolic RN 52-78-8 MF C20H30O2 MW EINECS 200-153-5 CN 17a -17-hydroxy-19-norpregn-4-en-3-one norethisterone q- v. Reference s US 2 721 871 Searle 1955 appl. 1954 . alternative synthesis US 2 691 028 Searle 1954 prior. 1952 . Colton . et al. J. Am. Chem. Soc. JACSAT 79 1123 1957 . Formulation s tabl. lOmg Trade Name s F Nilevar Laphal GB Nilevar Searle wfm USA Nilevar Coastal wfm Norethisterone Norethindrone ATC G03AC01 G03DC02 Use progestogen RN 68-22-4 MF C20H26O2 MW EINECS 200-681-6 LD50 6 g kg M . CN 17a -17-hydroxy-19-norpregn-4-en-20-yn-3-one 3-0-methylestrone 1. Li NH3 2. CrO3 CHjCOOH 1. lithium ammonia 2. chromium Vl oxide 3 17-dioxo-19-nor-4-androstene I HjC 0 0 CH3 0 ch3 pyridine-HCI --------------- 3-ethoxy-1 7-OXO-19-nor- 3 5-androstadiene II orthoformic acid triethyl ester 1462 N Norethisterone acetate HC CH acetylene 1. K tert-amylote 2. HCI Reference s US 2 774 122 Syntex 1956 MEX-prior. 1951 . US 2 774 777 Syntex 1956 prior. 1952 . Djcrassi c. et al. J. Am. Chem. Soc. JACSAT 76 4092 1954 . alternative syntheses US 2 849 462 P. de Ruggieri 1958 appl. 1957 . Ringold . et al. J. Am. Chem. Soc. JACSAT 78 2477 1956 . Ringold et al. Ann. N. Y. Acad. Sei. ANYAA9 71 500 1958 . Ueberwasser H. et al. Helv. Chim. Acta J-ICACAV 34 344 1963 . Ullmanns Encykl. Tech. Chem. 4. Aufl. Vol. 13 31. Onken D. Meublein D. Pharmazie PHARAT 25 3 1970 . total synthesis of 3 17-dioxo- 19-nor-4-androstene DE 1 958 600 Hoffmann-La Roche appl. USA-prior. . Formulation s tabl. mg mg also in comb. Trade Name s D Conceplan Grünenthal - Noriday Searle F comb. Micronovum Janssen- Cilag TriNovum Janssen-Cilag -comb. numerous generics Norluten SmithKline Primolut N Schering Utovlan Searle numerous combination preparations I Trinovum Janssen-Cilag - comb. J Norluten D Shionogi GB Beecham Ortho-Novum 1 35 Janssen-Cilag -comb. Triella Cilag -comb. Micronor Janssen-Cilag .

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