TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 142

Pharmaceutical Substances Syntheses, Patents, Applications - Part 142. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nefazodone hydrochloride N 1411 in 0 0 ch3 O O CHj NaH DMF ----------- sodium hydride diethyl oxalate ch3 0 I CHjO H3c MYyyj o cH3 O 0 diethyl 9-ethyl-6 9-dihydro-10- propyl-4 6-diaxo-4H-pyrano 3 2-g - quinoline-2 8-dicorboxylote IV NaHCOj C2H5OH IV ------------------------ sodium hydrogen carbonate Reference s US 4 474 787 Fisons GB-prior. . DE 2 819 215 Fisons appl. GB-prior. . GB 2 022 078 Fisons appl. prior. . Cairns H. et al. J. Med. Chem. JMCMAR 28 1832 1985 . synthesis of2H 3H C-labelled nedochromil sodium Wilkinson . Lockley . J. Labelled Compd. Radiopharm. JLCRD4 22 883 1985 . combination with anticholinergics GB 2 204 790 Fisons appl. . Formulation s aerosol 2 mg puff eye drops 20 mg ml as sodium salt spray mg ml Trade Name s D Halamid ASTA Medica Tilade Syncroner Spécia Tilarin Rhône-Poulenc AWD Tivalist Spécia Rorer Irtan Fisons Rhöne- GB Rapitil Rhône-Poulenc I Kovilen Mediolanum Poulenc Rorer Rorer Tilade Italchimici Tilade Fisons Rhone- Tilade Syncroner Rhône- USA Tilade Rhône-Poulenc Poulenc Rorer 1988 Poulenc Rorer 1986 Rorer F Tilade Specia 1988 Nefazodone hydrochloride BMY-13754 MJ-13754-1 ATC N06AX06 Use antidepressant 5-HT2A-antagonist RN 82752-99-6 MF C25H32C1N5O2 HC1 MW CN 2- 3- 4- 3-chlorophenyl -l-piperazinyl propyl -5-ethyl-2 4-dihydro-4- 2-phenoxyethyl -3 -l 2 4-triazol- 3-one hydrochloride base RN 83366-66-9 MF C25H32C1NSO2 MW 1412 N Nefazodone hydrochloride 1 - 3 Chlorophenyl -4- 3-chloropropyl -piperozine I N2H4 H20 ethanol ------------ ---------- 1 - 3-chlorophenyl -4- 3-hydrozînopropyl -piperozine II éthanol - H2S 2- 3- 4- 3-chlarophenyl -1 - piperazinyl propyl -5-ethyl-2 4-dihydro-3H-1 2 4-triozal-3-ane DI N-ethoxy-carbonylthio-propionqmlde 2-phenoxy-ethyl bromide 1. NoOH xylene 2. HCl ethanal ----------------- phenol COCI2 phosgene IV H N NH 0 o ch3 NaOH A --------- V a n 0 methyl carbozate V 1. NoOH 2. HCI ---- ---- .

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