TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 140

Pharmaceutical Substances Syntheses, Patents, Applications - Part 140. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nalorphine N 1391 monohydrochloride RN 58895-64-0 MF C21H25NO3 HCI MW -base RN 131378-67-1 MF C21H25NO3 MW -monohydrochloride RN 131712-55-5 MF C2 H25NO3 HCl MW Reference s Hahn . et al. J. Med. Chem. JMCMAR 18 259 1975 . synthesis ỡ nalmefene from naltrexone US 7 421 900 Nat. Inst of Health appl. USA-prior. . US 4 322 426 Du Pont de N. appl. USA-prior. . US 4 751 307 Mallinckrodt Inc. appl. USA-prior. . EP 140 367 Key Pharm. Inc. appl. USA-prior. . use öfnalmefene US 4 880 813 Baker Cummins Pharm. appl. USA-prior. . WO 8 910 125 Baker Cummins Pharm. appl. USA-prior. . WO 8 702 586 Key Pharmaceuticals appl. . US 4 639 455 Key Pharmaceuticals appl. USA-prior. . US 4 863 928 Baker Cummins Pharm. appl. USA-prior. . US 4 877 791 Baker Cummins Pharm. appl. USA-prior. . US4923 875 Baker Cummins Pharm. appl. . WO 9 218 126 Baker Cummins Pharm. appl. USA-prior. . WO 9 118 605 Finland appl. USA-prior. . formulation US 4 511 570 Key Pharmaceuticals appl. . combination WO9 531 985 Italy appl. 1-prior. . Formulation s amp. 100 lg ml 2 mg 2 ml syringe 2 mg 2 ml as hydrochloride Trade Name s USA Revex Ohmeda Nalorphine ATC V03AB02 Use morphine antagonist RN 62-67-9 MF C19H21NO3 MW EINECS 200-546-1 LD5I 127 mg kg M . 1140 mg kg M . 226 mg kg R . CN 5a 6a -7 8-didehydro-4 5-epoxy-17- 2-propenyl morphinan-3 6-diol 1392 N Naloxone hydrochloride RN 57-29-4 MF CI9H21NO3 HCl MW EINECS 200-321-8 LD . 63 mg kg M . 1150 mg kg R . 120 mg kg dog . hydrobromide RN 1041-90-3 MF C19H21NO3 HBr MW EINECS 213-868-2 LD5l 260 mg kg M . 921 mg kg M . morphine O 0 0 CH diamorphine BrCN I cyanogen bromide Reference s US 2 364 833 Merck Co.

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