TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 139

Pharmaceutical Substances Syntheses, Patents, Applications - Part 139. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nabilone N 1381 Nabilone ATC A04 Use anti-emetic controlled substance RN 51022-71-0 MF C24H36O3 MW LDW 1000 mg kg M . 1000 mg kg R . 1 mg kg dog . 5 mg kg dog . CN trans- -3- . 1 1 -dimethylheptyl -6 6a 7 8 10 1 0a-hexahydro-1 -hydroxy-6 6-dimethyl-97 -dibenzo b J pyran-9-one benzaldehyde 1. h2 PtO2 2. SOCI2 3. NaCN ----------- 2. thionyl chloride 3. sodium Ck CH3 I CH3 NaNH2 ------------------- methyl iodide sodium amide n-pentylmagnesium bromide OH 5- l 1 -dimethylheptyl -resarcinol II 0. CH3 1. H2 copper chromite 2. HCI 3. H2. Pd-C --------------------- Il POCb phosphoryl chloride diethyl 2-acetyl- glutarate ethylene glycol V 1382 N Nabumetone H3C CH v H3C Mgl methylmagnesium iodide Reference s DOS 2 451 934 Eli Lilly appl. USA-prior. . DOS 2 451 932 Eli Lilly appl. USA-prior. . US 3 944 673 Eli Lilly prior. . US 3 928 598 Eli Lilly prior. . US 3 953 603 Eli Lilly prior. . synthesis o 5- 1 1 -dimethylheptyl resorcinol Adams R. et al. J. Am. Chem. Soc. JACSAT 70 664 1948 . Formulation s cps. 1 mg Trade Name s GB Cesamet Lilly wfm Nabumetone ATC M01AX01 Use analgesic anti-inflammatory NSAI RN 42924-53-8 MF C15H16O2 MW LDJ0 2380 mg kg M . 4290 mg kg M . 1520 mg kg R . 3880 mg kg R . CN 4- 6-methoxy-2-naphthalenyl -2-butanone 6-methaxy-2- acetone 4- 6-methaxy-2-naphthyl -3-buten-2-one 1 naphthaldehyde Nadolol N 1383 Reference s DE 2 463 219 Beecham appl. GB-prior. . DE 2 442 305 Beecham appl. GB-prior. . US4061 779 Beecham GB-prior. . US 4420 639 Beecham GB-prior. . alternative syntheses EP 376 516 Hoechst Celanese appl. USA-prior. . JP2 101 038 Beecham appl. GB-prior. . ES 8 507 452 Bioiberica appl. . Govdic . et al. J. Med. Chem. JMCMAR 21 1260 1978 .

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