TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 31

Pharmaceutical Substances Syntheses, Patents, Applications - Part 31. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Butenafine B 301 dimaleate RN 1063-55-4 MF C24H31N3OS 2C4H4O4 MW EINECS 213-900-5 LD50 mg kg M . 296 mg kg M . 63 mg kg R . 264 mg kg R . mg kg dog . 2-butyrylphenothiazine piperozine 1. NaNH2 2 HJC NvZN Cl ------------------ 1. sodium amide 2. 1 -methyl-4- 3-chloropropyl - H3C N o Butaperozine Reference s DE 1 120 451 Bayer appl. . US 2 985 654 Schering Corp. appl. . Formulation s tabl. mg mg mg Trade Name s . D Ôstrogynal Asche -comb. USA Repoise Robins wfm wfm Butenafine Use antifungal for topical use RN 101828-21-1 MF C23H27N MW CN N- 4- 1 1 -Dimethylethyl phenyl methyl -A -methyl-1 -naphthalenemethanamine hydrochloride RN 101827-46-7 MF C23H27N HC1 MW 0 naphthalene-1-corboxaldehyde II. 1-chloramethyl-nophthalene III H2 Roney-Nt. C2H50H h2n ch3 ---------------------- methylomine I N-methyl- 1 -nophthyl-methylamine 11 C2H5OH --------n 302 B Butenafine N-methyl-4-tert-butyl-benzylamine IV 4-tert-butyl- benzoldehyde 1. No2CO3 dmf 2. HCl C9Hr0H IV ni Butenafine benzoic acid Butenafine Butenofine Reference s a EP Mitsui Toatsu Chem. appl. J-prior. . b JP 03 200 747 Kokai Tokkyo Koho appl. J-prior. . c d EP 164 697 Kaken Pharmaceutical Co. appl. J-prior. . preparation ọ W-methyl-1 -naphthylmethylamine Daim Zoller Helv. Chim. Acta HCACAV 35 1348 1353 1952 . Elslager Johnson . Werbel . J. Med. Chem. JMCMAR 24 2 140 1981 . Baltzly L J. Am. Chem. Soc. JACSAT 65 1984 1943 Lutz et al. J. Org. Chem. JOCEAH 12 760 1947 Formulation s cream 1 sol. 1 als hydrochloride Trade Name s J Mentax Kaken 1992 Volley Hisamitsu USA Mentax Bertek Pharms. Butetamate B 303 Butetamate Butethamate ATC S01FA Use antispasmodic RN 14007-64-8 MF C16H25NO2 MW EINECS 237-817-9 CN a-ethylbenzeneacetic acid 2- diethylamino ethyl ester citrate RN 13900-12-4 MF C16H25NO2 xC6H8O7 MW unspecified EINECS 237-671-6 2-phenyl-butyric acid N

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