TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 127

Pharmaceutical Substances Syntheses, Patents, Applications - Part 127. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Mesna M 1261 medical use for treatment of dermatological disorders EP 352 826 Gist-Brocades appl. N-prior. . medical use for treatment of psoriasis EP 291 159 Dak-Lab. appl. GB-prior. . medical use for treatment of colitis ulcerosa and Crohn s disease WO 8 102 671 Ferring appl. . medical use for treatment of coronary circulation diseases WO 8 903 216 Ferring appl. DK-prior. . soluble pharmaceutical formulations DOS 3 151 196 K. H. Bauer appl. . US 4 664 256 Ferring prior. . controlled-release formulation EP 131 485 Rowell Lab. appl. USA-prior. . Formulation s rectal susp. 2g 30 ml 4 g 60 ml suppos. 250 mg 500 mg tabl. 250 mg 400 mg 500 mg Trade Name s D Asacolitin Henning GB Asacol SmithKline Salofalk Interfalk Berlin Claversal Merckle SmithKline Beecham Beecham Pentasa Yamanouchi Salofalk Thames J Pentasa Kyorin Nisshin Kyorin USA Asacol Procter Gamble Pentasa Ferring Salofalk Falk I Asacol Giuliani Claversal Smith Kline Pentasa Hoechst Marion Roussel F Pentasa Ferring Rowasa Solvay Pharma French Pentasa Brocades Rowasa Solvay Mesna atc RO5CBO5 vosafoi Use detoxificant mucolytic agent RN 19767-45-4 MF C2H5NaO3S2 MW EINECS 243-285-9 LDS0 1720 mg kg M . 6102 mg kg M . 1510 mg kg R . 4440 mg kg R . CN 2-mercaptoethanesulfonic acid free acid RN 3375-50-6 MF C2H6O3S2 MW EINECS 222-167-0 h2n Br SO3H thiourea 2-bromo-ethanesulfanic acid NH NaOH w xONa h2n J s S03h k Mesna Reference s US 2 695 310 Lever Brothers 1954 appl. 1951 . Schramm . et al. J. Am. Chem. Soc. JACSAT 77 6231 1955 . US 3 567 835 UCB GB-prior. - only medical use. from ethylenesulfide and sodium hydrogen sulfite Reppe W. Justus Liebigs Ann. Chem. JLACBF 601 127 1956 . from 2-chloroethanesulfonic acid and NaSH DRP 619 299 Henkel appl. 1933 . 1262 M Mesoridazine de toxicant for therapy with cyclophosphamide and ifosfamide DAS 2 756 018 .

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