TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 125

Pharmaceutical Substances Syntheses, Patents, Applications - Part 125. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Menadione sodium bisulfite M 1241 Trade Name s F Bilkaby Lehning J generic Menadione sodium bisulfite Menaphthone sodium bisulfite ATC All Use antihemorrhagic vitamin RN 130-37-0 MF CnH9NaO5S MW EINECS 204-987-0 CN 1 2 3 4-tetrahydro-2-methyl-1 4-dioxo-2-naphthalenesulfonic acid sodium salt NoHSO 0 Menadione sadium bisulfite Reference s Moore . J. Am. Chem. Soc. JACSAT 63 2049 1941 . Baker . et al. J. Am. Chem. Soc. JACSAT 64 1096 1942 . Ménotti . J. Am. Chem. Soc. JACSAT 65 1209 1943 . US 2 367 302 Abbott 1945 appl. 1940 . Formulations amp. 1 mg 2 mg 3 mg 10 mg 50 mg Trade Name s D Chloramsaar Chephasaar - Poly-Vitamin-Saar F Arhémapectine vitaminée comb. wfm Geriatrie-Mulsin Mucos -comb. wfm Chephasaar -comb. wfm Prenatal Cyanamid -comb. wfm Gallier -comb. wfm CépévitK UCB -comb. wfm Lentinorm Kanoldt -comb. wfm Tetracycletten Voigt wfm I J Vitamina K Salf Salf Menadione Inj. Nord - -Menthol Use anesthetic combination ingredient in antitussives and expectorants RN 2216-51-5 MF Cl0H20O MW EINECS 218-690-9 LD5o 3400 mg kg M . 3300 mg kg R . CN 1 R- 1 a 2ß 5 -5-methyl-2- 1 -methylethyl cyclohexanol 1242 M - -Menthol isolation from peppermint oils containing 70-80 free menthol by freezing ond recrystollizotion b from -citronellol containing at 80 in citronellol -neoisoiso- -citronellal I - -isopulegol II -neoiso- -isoiso- pulegol III pulegol IV pulegol V H2 Raney Ni n ----------------- h3c ch3 -Menthol pyrolysis thymol -menthol VI -neomenthol -isomenthol recycling epimerization to the ratio -menthol -neomenthol -isomenthol -6 3 1 under hydrogenation conditions separation of -menthol by distillation pyridine --------- 1. fract. crystallization 2. hydrolysis with NaOH k - -Menthol -menthyl benzoate -Menthol can be racemized under thymol hydrogenation conditions also with Raney-Ni . Reference s review Ullmanns Encykl. Tech Chem. 4. Aufl. Vol. 20 220. b DAS 1 197 081 A. Boake Roberts Co. appl. . c racemate resolution of -menthyl .

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