TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 178

Pharmaceutical Substances Syntheses, Patents, Applications - Part 178. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Quinapril hydrochloride Q 1771 HOBt THF N C2H5 3 DCC 3-5 C ------------------------------------ 1 -hydroxybenzotriazole IV V 1. CFjCOOH 2. NaOH 3. HCl ---------- Quinapril hydrochloride polyphosphoric acid --------- -------- benzyl alcohol benzyl s 3 4-tetrahydro-3-isoquinolìne-carboxylate VI VI Il 2. H2 Pd-C 3. HCI ---------------------------- 1. 1-hydroxybenzotriazole dicyclohexylcarbodiirnlde Quinapril hydrochloride Referenceis a EP 49 605 Warner-Lambert appl. USA-prior. . US 4 344 949 Warner-Lambert appl. prior. . Klutchko S. et al. J. Med. Chem. JMCMAR 29 1953 1986 . b EP 49 605 Warner-Lambert appl. USA-prior. . US 4 344 949 Warner-Lambert appl. prior. . crystalline quinapril hydrochloride EP 285 992 Warner-Lambert appl. USA-prior. . US 4761 479 Warner-Lambert appl. . preparation of ethyl 2-bromo-4-phenylbutanoate and 2-bromo-4-phenylbutanoic acid Fischer E. Schmitz Ber. Dtsch. Chem. Ges. BDCGAS 39 2212 1906 . Baxter . et al. Bioorg. Med. Chem. Lett. BMCLE8 7 21 2765 1997 . Iwasaki G. Kimura R. Numao N. Kondo K. Chem. Pharm. Bull. CPBTAL 37 2 280 1989 . Coric P. et al. J. Med. Chem. JMCMAR 39 6 1210 1996 . Goel . Krolls K. Tetrahedron Lett. TELEAY 24 2 163 1983 . stabilization of pharmaceutical formulations EP 264 887 Warner-Lambert appl. USA-prior. . EP 264 888 Warner-Lambert USA-prior. . EP 280 999 Warner-Lambert appl. USA-prior. . Formulation s f. c. tabl. 5 mg 10 mg 20 mg 40 mg 1772 Q Quinestrol Trade Narne s D Accupro Gödecke Parke Davis 1991 Accuzide Godecke Parke Davis -comb. F Acuilix Parke Davis - comb. Acuitel Parke Davis 1990 Korec Sanofi Winthrop Koretic Sanofi Winthrop -comb. GB Accupro Parke Davis I Accuprin Parke Davis 1989 Acequin Recordati 1989 Quinazil Malesci 1989 J Conan Yoshitomi-Green Cross USA Accupril Parke

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