TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 221

Pharmaceutical Substances Syntheses, Patents, Applications - Part 221. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Zipeprol Z 2201 Reference s FR 2 134 379 AB Hassle appl. S-prior. . alternative syntheses BE 835 802 Astra appl. S-prior. . SU 650 501 Pharmastra appl. . Formidationtsj 100 mg 200 mg as dihydrochloride Trade Name s D Normud Astra wfm GB Zelmid Astra wfm Zipeprol ATC R05DB15 Use antitussive RN 34758-83-3 MF C23H32N2O3 MW EINECS 252-191-7 CN 4- 2-methoxy-2-phenylethyl -a- methoxyphenylmethyl -l-piperazineethanol dihydrochloride RN 34758-84-4 MF C23H32N2O3 2HC1 MW EINECS 252-192-2 LD5 mg kg M . 300 mg kg M . mg kg R . 435 mg kg R . 228 mg kg dog . HO CHj H3C 3C-O-Br tert-butyl hypobromite NH ---------- piperozine styrene 1 2-methoxy-2- 1 2-methoxy-2- phenylethyl phenylethyl - bromide piperazine II cinnamy alcohol H3C 3C-O-Br --------------- tert-butyl hypobromite NaOH ------ 1 2-epoxy-3-methoxy-3-phenyl-propane HI 2202 Z Ziprasidone hydrochloride n Reference s US 3 718 650 Mauvernay F-prior. . DE 2 109 366 CERM appl. prior. . Formidation s drg. 75 mg syrup as dihydrochloride Trade Name s F Respilene Winthrop 1973 I Zitoxil Italfarmaco 1979 Ziprasidone hydrochloride CP-88059-1 Use antipsychotic dopamine D2-antagonist 5-HT2-antagonist RN 138982-67-9 MF C21H21C1N4OS HC1 H2O MW CN 5- 2- 4- l 2-Benzisothiazol-3-yl -l-piperazinyl ethyl -6-chloro-l 3-dihydro-2 7-indol-2-one hydrochloride hydrate base RN 146939-27-7 MF C21H21C1N4OS MW hydrochloride RN 122883-93-6 MF C21H21C1N4OS HC1 MW mesylate RN 185021-64-1 MF C21H21C1N4OS CH4O3S MW 0 h2n-nh2 C2H50H NqOCHj ----------------- hydrozine chloroacetyl chloride 0 6-chloroisatin 6-chlorooxindole I CH3 HjC SkxCH 3 H 3 CFjCOOH --------------- triethylsilane trifluoroacetic acid 6-chloro-5- 2-chloroethyl -oxindole II Ziprasidone hydrochloride Z 2203 NH 1- 1 2-benzîso-thiozol-3-yl -piperazine III 1. No2COj. H2O 2. HCl H2O H s n 1. P0Cl3 2. HhK 2. pîperozine III 1 .

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