TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 208

Pharmaceutical Substances Syntheses, Patents, Applications - Part 208. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Toliprolol T 2071 ÇOOH ci Cu 2-bromo-benzoic acid 2. 3-chloro-2-methyl-oniline copper Tolfenomic ocid Reference s US 3 313 848 Parke Davis prior. . Formulation s cps. 100 mg 200 mg s. r. tabl. 300 mg Trade Name s J Clotam Tobishi Shingaku . Toliprolol ATC C07AA Use antiarrhythmic antihypertensive antianginal RN 2933-94-0 MF CI3H21NO2 MW EINECS 220-905-6 LD50 mg kg M . CN 1 - 1 -methylethyl amino -3- 3-methylphenoxy -2-propanol hydrochloride RN 306-11-6 MF C13H21NO2 HC1 MW EINECS 206-177-2 LD50 40 mg kg M . 3-methylphenol NoOH epichlorohydrin h2nxth3 isopropyl-omine ch3 3- 3-methylphen-oxy propylene oxide ch3 Toliprolol OH H Reference s DOS 1 493 454 Boehringer Ing. appl. . NL-appl. 6 409 883 Boehringer Ing. appl. . Formulation s tabl. 10 mg 50 mg Trade Name s D Doberol Boehringer Ing. wfm Tolmetin ATC M01AB03 M02AA21 Use anti-inflammatory RN 26171-23-3 MF C15H15NO3 MW EINECS 247-497-2 LD5 680 mg kg M . 914 mg kg M . 293 mg kg R . CN l-methyl-5- 4-methylbenzoyl -l -pyrrolc-2-acetic acid 2072 T Tolmetin sodium sait RN 35711-34-3 MF C15H14NNaO3 MW EINECS 252-687-3 LDW 622 mg kg M . 899 mg kg M . 724 mg kg R . 914 mg kg R . 800 mg kg dog . sodium sait dihydrate RN 64490-92-2 MF C15HI4NNaO3 2H2O MW H C O H N. chj 2-dimethylamino-methyl-1 -methylpyrrole 1-methyl- form- dimethyl- pyrrole oldehyde omine I CHj ÇH3 ----- PH3 i- i Y Ni H CH3 I 4- NaCN 1 -methyl-2-pyrrolyl -acetonitrile 4-methylbenzoyl chloride Reference s US 3 752 826 McNeil prior. . DAS 1 770 984 McNeil appl. USA-prior. . Carson J R. et al. J. Med. Chem. JMCMAR 14 646 1971 . GB 1 428 272 McNeil appl. USA-prior. . DOS 2 102 746 McNeil appl. USA-prior. . DOS 2 339 140 McNeil appl. USA-prior. . Friedel-Crafts-synthesis without use of A1C13 DAS 2 511 256 Ethyl Corp. appl. .

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