TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 88

Pharmaceutical Substances Syntheses, Patents, Applications - Part 88. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Fluazacort F 871 ni 2. Br2 CHCI Q 3. JÍ KCr CH-. 1. HBr AcOH 30 5a 5 0 -21 -acetoxy-3-hydroxy-2 -methyl-5H-pregn-9 11 -eno 17 16-dJ-oxazol-20-one IV 1. HBr CHjCOOH Br2 dioxane 2. KOAc 3. DMF LiBr LijCOj 5 0 -21 -acetoxy-2 methyl- 5 H-pregna-1 4 9 11 -trieno 17 16-d - oxazole-3 20-diane VI 1. Ac2O pyridine 2. CH3SO2CI 3- NaCTTH3 -------- ---- 2. mesyl chloride 1. KOH n h3ç cn 3. HjC COOH N C2H5 3 ni ------------------- ------------ IV 2. iodine ozoisobutyronitrile 3. triethylammonium acetate 5a 5 0 -30 1 ự-dihydroxy- 2 -methyl-5 H-pregnano- 17 16-d oxazol-20-one et. Deflazacort 1. CrO 2. Br2 3. LÍ9CO-1 IV ------- -- . VI .Helo J H 2. NaOH 3. HF 4. Ac2O pyridine 1. N-bromoocetamide Fluazacort Reference s a DOS 1 618 613 Lepetit appl. GB-prior. . US 3 461 119 Lepetit appl. 1967 GB-prior. . 872 F Flubendazole synthesis of starting compound DE 1 568 971 Gruppo Lepetit appl. GB-prior. . US 3 624 077 Gruppo Lepetit GB-prior. . Nathansohn G. et al. J. Med. Chem. JMCMAR 10 799 1967 . Nathansohn G. et al. Gazz. Chim. Ital. GCITA9 95 1338 1965 . review Nathanson G. et al. Steroids STEDAM 13 365 1969 . alternative synthesis of VI DOS 1 568 971 Lepetit appl. GB-prior. . DOS 1 568 972 Lepetit appl. GB-prior. 1966 . b Nathansohn G. et al. 1. Med. Chem. JMCMAR 10 799 1967 . Nathansohn G. et al. Steroids STEDAM 13 383 1969 . Formulation s cream Trade Name s I Azacortid crema Lepetit Flubendazole atc po2Caos Use anthelmintic RN 31430-15-6 MF C16H12FN3O MW EINECS 250-624-4 LD50 2560 mg kg M . 2560 mg kg R . CN 5- 4-fluorobenzoyl -lH-benzimidazol-2-yl carbamic acid methyl ester AICI3 m aluminum chloride 3-chloro-4-nitro- fluorobenzene 3-chloro-4-nitro- 1. NH3 ch3oh sulfolane 125 C 2. H2. Pd-C. HCI CH3OH ----- ------------ benzoyl chloride CHj Cl Ĩ1 11

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