TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 14

Pharmaceutical Substances Syntheses, Patents, Applications - Part 14. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Apraclonidine A 131 morphine HCI Referenceis Small L. et al. J. Org. Chem. JOCEAH 5 334 1940 . Formulation s amp. 10 mg inj. sol. 10 mg 1 ml 5 mg 1 ml tabl. 3 mg Trade Namefsj F Apokinon Aguettant GB Britagel Britannia as hydrochloride I Apomor Tariff. Integrativo as hydrochloride Apraclonidine Aplonidine ATC Use S01EA03 selective -agonist for postsurgical control of intraocular pressure RN 66711-21-5 MF C9H1OC12N4 MW CN 2 6-dichloro- V1-2-imidazolidinylidene-1 4-benzenediamine monohydrochloride RN 73218-79-8 MF C9H1OC12N4 HCI MW LD50 6 mg kg M . 3 mg kg M . 9 mg kg R . 38 mg kg R . dihydrochloride RN 73217-88-6 MF C9H1OC12N4 2HC1 MW 2 6-dichloro-4-nitroaniline 1. H2. Roney Ni 2- _JL . N C2H5 3 2. trichloroocetyl chloride HCOOH ch3co 2o ---------- formic acid N- 4-amino-3 5- I dichlarophenyl - trichloroacetamide Cl SOCI2 SO2CI2 thionyl chloride sulfuryl chloride H 1. H2N - NH N- 4 dichlaromethylene- mino -3 5-dichforo-phenyljtrichloroacet-amide 132 A Aprindine Reference s EP81 924 Alcon appl. USA-prior. . EP 81 923 Alcon appl. USA-prior. . US 4 461 904 Alcon prior. . Ronot B. Leclerc G. Bull. Soc. Chim. Fr. BSCFAS Pt. 2 520 1979 . combination with fi-receptor antagonist EP 365 662 Alcon USA prior. . preparation of 2 6-dichloro-4-nitroaniline Goldschmidt Strohmenger. Ber. Dtsch. Chem. Ges. BDCGAS 55 2455 1922 . Pausadeer Scroggie Aust. J. Chem. AJCHAS 12 430 432 1959 . Fluerscheim J. Chem. Soc. JCSOA9 93 1774 1908 . Datta Muller J. Am. Chem. Soc. JACSAT 41 2036 1919 . Koerner Gazz. Chim. Ital. GCITA9 4 376 1874 . Kohn Pfeifer Monatsh. Chem. MOCMB7 48 236 1927 . Formulation s eye drops 1 ophthalmic sol. 10 mg ml Trade Name s D lopidine Alcon F lopidine Alcon GB lopidine Alcon USA lopidine Alcon 1988 wfm Aprindine ATC C01BB04 Use antiarrhythmic RN 37640-71-4 MF. C22H30N2 MW LD50 274 mg kg M . CN A- 2 3-dihydro-177-inden-2-yl -W W-diethyl-

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