TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 72

Pharmaceutical Substances Syntheses, Patents, Applications - Part 72. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Doxazosin D 711 1. NoNH 1. sodium amide 2. 1 -ethyl-3-chlora pyrrolidine h2so4 diphenylacetonitrile Reference s US 3 192 230 A. H. Robins prior. . Lunsford . et al. J. Med. Chem. JMCMAR 7 302 1964 . Formulation s amp. 20 mg ml Trade Name s D Dopram Brenner wfm I F Dopram Martinet wfm GB Dopram Anpharm Doxapril Carlo Erba wfm Doxapril Farmalabor wfm J Dopram Kissei USA Dopram Robins as hydrochloride Doxazosin ATC C02CA04 Use arreceptor antagonist antihypertensive RN 74191-85-8 MF C23H25N5O5 MW LD50 1000 mg kg M R . CN l- 4-amino-6 7-dimethoxy-2-quinazolinyl -4- 2 3-dihydro-l 4-benzodioxin-2-yl carbonyl piperazine hydrochloride RN 70918-01-3 MF C23H25N5O5 HCl MW mesylate RN 77883-43-3 MF C23H25N5O5 CH4O3S MW LDS0 2935 mg kg M . 5 g kg R . 1 g kg dog . 0 0 piperazine 1 4-benzodioxan-2-ylcarbonyl chloride N- 1 4-benzodioxan-2-ylcarbonyl piperazine I 712 D Doxefazepam 1 4-amino 2-chloro-6 7-dimethaxyquinazoline cf. prozasine synthesis Reference s DE 2 847 623 Pfizer appl. GB-prior. . US 4 188 390 Pfizer GB-prior. . EP 848 001 Alfa Chem. appl. I-prior. . WO 9 935 143 Knoll appl. D-pnor. medical use for treatment of atherosclerosis US 4 758 569 Pfizer appl. . osmotic device US 4 837 111 Alza appl. . Formulation s tabl. 1 mg 2 mg 4 mg Trade Name s D Cardular Pfizer 1989 as I Cardura Roerig 1989 as Normothen Fisons mesylate mesylate Italchimici 1989 as Diblocin Astra 1989 as Dedralen Lifepharma mesylate mesylate 1989 as mesylate J Cardenalin Pfizer GB Cardura Invicta 1989 as USA Cardura Pfizer 1990 as mesylate mesylate Doxefazepam ATC N05CD12 Use hypnotic RN 40762-15-0 MF C17H 4C1FN2O3 MW LD50 74 mg kg M . 1500 mg kg M . 586 mg kg R . 1500 mg kg M . CN 7-chloro-5- 2-fluorophenyl -l 3-dihydro-3-hydroxy-l- 2-hydroxyethyl -2 7-l 4-benzodiazepin-2-one hci 0 0 . X - ---------- 1 .

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