TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 3

Pharmaceutical Substances Syntheses, Patents, Applications - Part 3. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Acetylcholine Chloride A 21 hydroxide RN 56-13-3 MF C7H17NO3 MW 163 22 bromide RN 66-23-9 MF C7Hi6BrNO2 MW EINECS 200-622-4 LD5 170 mg kg M . er ci ch3 CH M r 0 CI 0H 3 0H ------------ H c -CH HjC cHj trimethyl- 2-chioro- choline cr YCH ch3 Acetylcholine chloride omine I ethanol n chloride in p HiC t CH- IV ---- Acetylcholine chloride 0 ethylene oxide OH H3C CH choline hydroxide Acetylcholine chloride 0 Acetylcholine chloride 2-chloroethyl acetate Reference s Baeyer A. V. Justus Liebigs Ann. Chem. JLACBF 142 235 1867 . Nothnagel Arch. Pharm. Weinheim Ger. ARPMAS 232 265 1894 . Fourneau E. Page . Bull. Soc. Chim. Fr. BSCFAS 4 15 544 1914 . DE 801 210 BASF appl. 1948 . US 1 957 443 Merck Co. 1934 appl. 1931 . US 2 012 268 Merck Co. 1935 appl. 1931 . US 2 013 536 Merck Co. 1935 appl. 1931 . Formuiation s amp. 20 mg eye drops 1 Trade Name s D Miochol-E CIBA Vision J I Farmigea acetilcolina Farmigea wfm Acetylcholine Roche Neucholin-A Zeria wfm Ovisot Daiichi wfm 22 A Acetylcysteine Acetylcysteine ATC R05CB01 S01XA08 V03AB23 Use mucolytic agent RN 616-91-1 MF C5H9NO3S MW EINECS 210-498-3 LD5o 400 mg kg M . 3800 mg kg M . 7888 mg kg M . 1140 mg kg R . 5050 mg kg R . 700 mg kg dog . 700 mg kg dog . 1 g kg dog . CN IV-acctyl-L-cysteine monosodium salt RN 19542-74-6 MF C5H8NNaO S MW EINECS 243-143-6 LD30 3800 mg kg M . 2559 mg kg R . monoammonium salt RN 50807-78-8 MF C5H9NO3S H3N MW NH. HCL H2 H2O COOH L-cysteine hydrochloride monohydrate 0 0 3 acetic anhydride CH COONa _ --- His CH 3 HS - A COOH Acetylcysteine Reference s US 3 091 569 Mead Johnson . appl. . US 3 184 505 Mead Johnson appl. . Smitlp . Gorin G. J. Org. Chem. JOCEAH 26 820 1961 . ammonium sail mucolysis of bronchial mucus by nebulization DOS 2 305 271 Bristol-Myers appl. USA-prior. . Formulation s amp. 300 mg as monosodium salt cps. 200 mg eff. tabl. 100 mg 200 mg 600 mg f. c. tabl. 100

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