TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 69

Pharmaceutical Substances Syntheses, Patents, Applications - Part 69. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Dipivefrine D 681 2-chloro-3 4 -dlhydroxy-acetophenone h2n ch3 methylamine pivaloyl chloride 1 - 3 4-dipivoloyloxy- phenyl -2- benzyl- methylomino ethon-1 -one H2 Pd-C Dipivefrine Reference s a DOS 2 343 657 Interx Res. Corp. appl. USA-prior. . US 3 809 714 Interx prior. also racemate resolution. Hussain A. Truelove . J. Pharm. Sei. JPMSAE 65 1510 1976 . b DOS 2 152 058 Klinge appl. . US 3 839 584. Formulation s eye drops 1 mg ml as hydrochloride Trade Name s D D-Epifrin Pharm-Allergan Thilodigon Alcon 1985 - J 1978 comb. Glaucothil Alcon 1978 F Propine Allergan Thiloadren Alcon 1980 - GB Propine Allergan 1984 comb. I Propine Allergan Pivalephrine Okami-S an ten 682 D Dipotassium clorazepate 1 Dipotassium clorazepate atc nosbaos Clorazepate dipotassium Use- tranquilizer RN 57109-90-7 MF CI6Hl0ClKN O KOH MW EINECS 260-565-6 LD50 173 mg kg M . 700 mg kg M . 279 mg kg R . 880 mg kg R . CN 7-chloro-2 3-dihydro-2-oxo-5-phenyl- H-1 4-benzodiazepine-3-carboxylic acid monopotassium salt compd. with potassium hydroxide free acid RN 23887-31-2 MF C MW EINECS 245-926-8 0 0 H3C O JV 0 CH3 -HCI nh2 diethyl aminomalonate hydrochloride . 2-amino-5- phenylchlorobenzo- magnesium nitrile bromide KOH Oipotassium clorazepate Reference s US 3 516 988 J. Schmitt F-prior. . DE 1 518 764 C. M. Industries . appl. F-prior. . DE 1 795 690 C. M. Industries . appl. . precursors DOS 1 795 832 C. M. Industries . appl. F-prior. . Formulation s cps. 5 mg 10 mg 20 mg drops 5 mg f. c. tabl. 20 mg 50 mg lyo. 50 mg 100 mg Trade Name s D Tranxilium 50 Sanofi Winthrop F Noctran 10 Menarini - comb. Tranxene Sanofi J Cephadol Nippon Winthrop Shinyaku GB Tranxene Boehringer Ing. USA Gen-XENE Alra I Transene Sanofi Winthrop Tranxene Abbott Diprophylline Diprofyllin Dyphylline ATC R03DA01 Use expectorant .

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