TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 52

Pharmaceutical Substances Syntheses, Patents, Applications - Part 52. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Clocortolone c 511 3-chloro-10 11 -di-hydro-5H-dibenz- Br CI NoNH2 ------ sodium amide b f azepine 1 -bromo-3-chloropropane 4-piperidino-piperidine-4-carboxamide cf. pipamperone synthesis DMF Reference s DOS 1 905 765 Yoshitomi appl. J-prior. . US 3 668 210 Yoshitomi J-prior. . Formulation s tabl. 10 mg 25 mg as hydrochloride Trade Name s J Clofekton Yoshitomi- Takeda 1974 Clocortolone ATC D07AB21 Use glucocorticoid RN 4828-27-7 MF C22H28C1FO4 MW EINECS 225-406-7 CN 6a 11 J 16a -9-chloro-6-fluoro-11 21 -dihydroxy-16-methylpregna-1 4-diene-3 20-dione pivalate RN 34097-16-0 MF C27H36C1FO5 MW EINECS 251-826-5 caproate RN 4891-71-8 MF C28H38C1FO5 MW EINECS 225-513-9 3 20-dioxa-6a-fluoro-21 -hydroxy-16a-methyl-1 4 9 1 l -pregnatriene 512 c Clodantoin Clocortolone H3CvCH3 h3c ch3 h3cXV tî ch3 0 o pivolic anhydride pyridine --------- Clocortolone Reference s NL-appl. 6 412 708 Schering AG appl. D-prior. . FR 6 752 M Schering AG appl. D-prior. . synthesis o f starting compound DOS 1 913 042 Schering AG appl. . alternative synthesis DOS 2 011 559 Schering AG appl. . Formulation s cream 1 mg g Trade Name s D Crino-Kaban Asche as pivalate-comb. Kaban Asche as pivalate and capronate-comb. Kabanimat Asche as pivalate and capronate Procto Kaban Asche as capronate -comb. I Cilder Cilag as pivalate wfm USA Cloderm Penederm as pivalate Clodantoin Chlordantoin ATC G01AX01 Use fungicide RN 5588-20-5 MF CuHpCljNzOjS MW EINECS 226-995-3 LD50 1165 mg kg R . CN 5- l-ethylpentyl -3- trichloromethyl thio -2 4-imidazolidinedione 0 5- 1 -ethylpentyl -hydontoin sodium soit Cl s-cci3 trichloromethyl- sulfenyl chloride Reference s US 2 553 770 Standard Oil 1951 prior. 1949 . r Clodronate disodium c 513 Formulations cream gel powder Trade Name s GB Sporostacin Ortho wfm USA Sporostacin Ortho -comb. J Gynelan Eisai -comb wfm Clodronate disodium atc mosbao2 Clodronic acid .

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