TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 45

Pharmaceutical Substances Syntheses, Patents, Applications - Part 45. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Chloroxy ỉenol c 441 1 Reference s a US 2 430 891 Merrell 1947 prior. 1941 . b BE 561 508 ICI valid from 1943 prior. 1942 . Formulations cps. 12 mg 24 mg 72 mg Trade Name s D Merbentul Marion Tace-FN Merrell- USA Chlotride Merck Co. Merrell wfm Toraude wfm wfm F Tace Merrell Dow wfm GB Tace Merrell wfm Diuril Merck Co. wfm I Anisene Farmila wfm Tace Merrell Dow wfm Chloroxylenol ATC D08AE05 Parachlorometaxylenol Use antiseptic RN 88-04-0 MF C8H9C1O MW EINECS 201-793-8 LD50 1 g kg M . 3830 mg kg R . CN 4-chloro-3 5-dimethylphenol 3 5-dỉmethyl-phenol Cl2 or SO2CI2 sulfuryl chloric Reference s US 2 350 677 W. Wiggins Cocker 1944 GB-prior. 1939 . Formulation s cream g 100 g powder g 100 g combination sol. 1 g 100 g combination Trade Name s D Bacillotox Bode -comb. I Dettol Manetti Roberts Cortic Everett Gehwol Gerlach -comb. wfm Zoto HC Horizon GB Rinstead Schering- Foille Delalande Isnardi - Plough -comb. comb. Zeasorb Stiefel -comb. USA Cortane-B Blansett 442 C Chlorphenamine Chlorphenamine Chlorpheniramine ATC R06AB04 Use antihistaminic RN 132-22-9 MF CI6HI9C1N2 MW EINECS 205-054-0 LD5 20 mg kg M . 121 mg kg M . 118 mg kg R . CN y- 4-chlorophenyl -A A-dimethyl-2-pyridinepropanamine maleate 1 1 RN 113-92-8 MF C16HiyClN2 C4H4O4 MW EINECS 204-037-5 LD50 mg kg M . 130 mg kg M . 306 mg kg R . mg kg dog . Cl NaNH2 ------- sodium omide 4-chlorophenyl - 2-pyridyl -ocetonitrile 1. NoNH2 2 CI CH3 ch3 1. sodium amide 2. 2- dimethylomino - ethyl chloride 1 4-chloro- 2-chloro- benzyl pyridine 4-chloro-benzyl chloride 2- 4-chlora-benzyl -pyridine --------- 1. sodium amide Chlorphenamine Reference s US 2 567 245 Schering Corp. 1951 prior. 1948 . US 2 676 964 Schering Corp. 1954 prior. 1950 . Fonnulaiion s amp. 10 mg cps. mg 4 mg 8 mg as maleate syrup 3 mg 15 ml Trade Natne s D Balkis Dolorgiet -comb. Codicaps Thiemann -comb. Contac SmithKline Beecham Grippostad Stada Sedotussin Rodleben UCB Vedim F

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